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Erastin

    
98.1%

Erastin

源叶(MedMol)
S80804 一键复制产品信息
571203-78-6
C30H31ClN4O4
547.04
MFCD09837984
4(3H)-Quinazolinone, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S80804-1mg买3赠1
98.1%

¥230.00

>10 9 4 - 3
S80804-2mg买3赠1
98.1%

¥300.00

>10 3 4 - -
S80804-5mg买3赠1
98.1%

¥420.00

>10 - 1 - -
S80804-10mg买3赠1
98.1%

¥630.00

>10 - - - -
S80804-25mg买3赠1
98.1%

¥900.00

>10 - - - -
S80804-50mg买3赠1
98.1%

¥1350.00

>10 1 - - -
S80804-100mg买3赠1
98.1%

¥2020.00

>10 - - - -
产品介绍 参考文献(22篇) 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述:

Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3)

产品溶液形式不稳定,建议现配现用。开封后保存请加封口膜和密封袋在干燥处保存。

靶点: Ferroptosis;VDAC
体内研究: Intraperitoneal injection of erastin at well-tolerated doses dramatically inhibits HT-29 xenograft growth in severe combined immunodeficient mice
参考文献: 1. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72. 2. Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79. 3. Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605.
溶解性: DMSO  :  20  mg/mL  (36.56  mM;  Need  ultrasonic)    H2O  :  <  0.1  mg/mL  (insoluble)
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 1.828 ml 9.14 ml 18.28 ml
5 mM 0.366 ml 1.828 ml 3.656 ml
10 mM 0.183 ml 0.914 ml 1.828 ml
50 mM 0.037 ml 0.183 ml 0.366 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献(22篇)

17. [IF=6.6] Yiting Yang et al."The Mechanism of Ferroptosis Regulating Granulosa Cell Apoptosis and Oxidative Stress Through the NF-κB/PTGS2 Axis in Porcine Atretic Follicles."Antioxidants.2025 Sep;14(9):1071 16. [IF=11.9] Xue Shi et al."NFS1, together with FXN, protects cells from ferroptosis and DNA damage in diffuse large B-cell lymphoma."Redox Biology.2025 Nov;87:103878 15. [IF=3.2] Wu Yujie et al."YLKTT, a potent biopeptide that ameliorates oxygen-glucose deprivation-induced neuronal cell ferroptosis by ACSL4/GPX4 and SLC7A11/GPX4 axis."JOURNAL OF PHARMACY AND PHARMACOLOGY.2025 Jul;: 14. [IF=8.3] Zhenxin Guan et al."A Specific Targeted Enhanced Nanotherapy Strategy for Inducing Ferroptosis by Regulating the Iron Pool Levels in Tumor Cells."ACS Applied Materials & Interfaces.2024;XXXX(XXX):XXX-XXX 13. [IF=4.4] Mengjiao Xue et al."Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4."Frontiers in Pharmacology.2025 Jan;15:1508312 12. [IF=5.7] He Jiani et al."Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner."Biology Direct.2025 Dec;20(1):1-15 11. [IF=14.7] Kexin Jia et al."Acteoside ameliorates hepatocyte ferroptosis and hepatic ischemia-reperfusion injury via targeting PCBP2."Acta Pharmaceutica Sinica B.2025 Mar;: 10. [IF=4] Yinhao ZHANG et al."Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis."Chinese Journal of Natural Medicines.2024 Sep;22:769 9. [IF=3.1] Jing Xin et al."Melatonin mitigates the lipopolysaccharide-induced myocardial injury in rats by blocking the p53/xCT pathway-mediated ferroptosis."NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.2024 Aug;:1-11 8. [IF=5.8] Muran Jiang et al."Copper oxide nanoparticles induce cuproptosis and ferroptosis through mitochondrial concatenation."Environmental Science-Nano.2024 Jul;: 7. [IF=5.3] Xue Xiaoyong et al."Si-Wu-Tang alleviates metabolic dysfunction-associated fatty liver disease by inhibiting ACSL4-mediated arachidonic acid metabolism and ferroptosis in MCD diet-fed mice."Chinese Medicine.2024 Dec;19(1):1-22 6. [IF=3.7] Xianqi Zhang et al."Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production."EXPERIMENTAL CELL RESEARCH".2024 May;438:114034 5. [IF=4.7] Sheng Hu et al."Ginsenoside Rd enhances blood-brain barrier integrity after cerebral ischemia/reperfusion by alleviating endothelial cells ferroptosis via activation of NRG1/ErbB4-mediated PI3K/Akt/mTOR signaling pathway."NEUROPHARMACOLOGY".2024 Jun;251:1 4. [IF=3.8] Zhang Yunwen et al."Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression."BMC CANCER.2023 Dec;23(1):1-15 3. [IF=3] Zhang Meixia et al."NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma."JOURNAL OF BIOENERGETICS AND BIOMEMBRANES.2023 Oct;:1-12 2. [IF=4.831] Ying Lan et al."Polysiloxane-based hyperbranched fluorescent probe for dynamic visualization of HClO in lysosomes and vivo."SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY.2023 Jun;294:122527 1. [IF=6.313] Yijia Yang et al."Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin."Antioxidants-Basel. 2022 Apr;11(4):710

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