Ferrostatin-1 (Fer-1)

36. [IF=12.8] Zhou Zhike et al."Inhibition of RACGAP1 sensitizes triple-negative breast cancer cells to ferroptosis by regulating CPT1A-dependent fatty acid metabolism."JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH.2025 Dec;44(1):323 35. [IF=8.3] Liuliang Zhang et al."Baitouweng decoction regulates ferroptosis-mediated mitophagy and apoptosis through the SLC7A11/GPX4/FTH1 pathway in ulcerative colitis."PHYTOMEDICINE.2026 Jan;:157898 34. [IF=3.1] Zhang Wei et al."Curcumin alleviates ferroptosis in CCl₄-induced acute liver injury in vitro: involvement of TXNIP/NLRP3 inhibition and SLC7A11/GSH/GPX4 activation."NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.2025 Oct;:1-14 33. [IF=6.6] Hanziyi Zhou et al."PK11007 Covalently Inhibits Thioredoxin Reductase 1 to Induce Oxidative Stress and Autophagy Impairment in NSCLC Cells."Antioxidants.2025 Oct;14(10):1222 32. [IF=8.5] Qi Wang et al."Quercetin inhibits silica nanoparticle-induced ferroptosis and inflammation by alleviating oxidative stress and targeting STAT3 in brain."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 Nov;331:148511 31. [IF=4.1] Yongchang Lai et al."Dioscin initiates dual roles in bladder cancer progression via miR-195–5p/FASN/SLC3A2 axis-mediated cell death mechanisms."Translational Oncology.2025 Nov;61:102534 30. [IF=4.7] Hui Hui et al."Muscone attenuates myocardial infarction by regulating ferroptosis of cardiomyocytes through Nrf2/system Xc-/GPX4 signaling pathway."INTERNATIONAL IMMUNOPHARMACOLOGY.2025 Oct;163:115270 29. [IF=4.7] Hui Hui et al."Muscone attenuates myocardial infarction by regulating ferroptosis of cardiomyocytes through Nrf2/system Xc-/GPX4 signaling pathway."INTERNATIONAL IMMUNOPHARMACOLOGY.2025 Oct;163:115270 28. [IF=2.5] Liu Jing-Jing et al."Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition."HEREDITAS.2025 Dec;162(1):1-10 27. [IF=6.8] Xiao-Hong Zhou et al."Platinum(IV) Prodrug with a Docosahexaenoic Acid Ligand Preferentially Accumulates in Drug-Resistant Cells and Triggers Ferroptosis to Overcome Drug Resistance."JOURNAL OF MEDICINAL CHEMISTRY.2025;XXXX(XXX):XXX-XXX 26. [IF=13] Hongshuai Wu et al."Postoperative Injection of a Triptolide-Preloaded Hydrogel Prevents the Recurrence of Glioblastoma by Dual-Pathway Activation of Ferroptosis."Small.2024 Oct;:2406036 25. [IF=5.5] Ling Wang et al."Thioredoxin reductase inhibition and glutathione depletion mediated by glaucocalyxin A promote intracellular disulfide stress in gastric cancer cells."FEBS Journal.2024 Oct;: 24. [IF=6.2] Hong-fei Wang et al."STING signaling contributes to methotrexate-induced liver injury by regulating ferroptosis in mice."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Nov;287:117306 23. [IF=4.4] Mengjiao Xue et al."Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4."Frontiers in Pharmacology.2025 Jan;15:1508312 22. [IF=14.7] Kexin Jia et al."Acteoside ameliorates hepatocyte ferroptosis and hepatic ischemia-reperfusion injury via targeting PCBP2."Acta Pharmaceutica Sinica B.2025 Mar;: 21. [IF=7.1] Tingting Wang et al."Endoplasmic reticulum stress-autophagy axis is involved in copper-induced ovarian ferroptosis."FREE RADICAL BIOLOGY AND MEDICINE.2025 Apr;: 20. [IF=4] Yinhao ZHANG et al."Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis."Chinese Journal of Natural Medicines.2024 Sep;22:769 19. [IF=3.1] Jing Xin et al."Melatonin mitigates the lipopolysaccharide-induced myocardial injury in rats by blocking the p53/xCT pathway-mediated ferroptosis."NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.2024 Aug;:1-11 18. [IF=5.3] Xue Xiaoyong et al."Si-Wu-Tang alleviates metabolic dysfunction-associated fatty liver disease by inhibiting ACSL4-mediated arachidonic acid metabolism and ferroptosis in MCD diet-fed mice."Chinese Medicine.2024 Dec;19(1):1-22 17. [IF=4] Yong-Zhuo Li et al."Naringenin enhances the efficacy of ferroptosis inducers by attenuating aerobic glycolysis by activating the AMPK-PGC1α signalling axis in liver cancer."Heliyon".2024 Jun;10: 16. [IF=13.6] Lin Zhang et al."Protective effects and mechanism of chemical- and plant-based selenocystine against cadmium-induced liver damage."JOURNAL OF HAZARDOUS MATERIALS".2024 Apr;468:133812 15. [IF=6.2] Hangping Chen et al."Butyrate ameliorated ferroptosis in ulcerative colitis through modulating Nrf2/GPX4 signal pathway and improving intestinal barrier."BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE.2024 Feb;1870:166984 14. [IF=9] Zhu Haixia et al."Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice."Cell Death & Disease.2023 Dec;14(12):1-14 13. [IF=3.8] Zhang Yunwen et al."Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression."BMC CANCER.2023 Dec;23(1):1-15 12. [IF=4.5] Feng Lian et al."Ubiquitin-specific peptidase 10 attenuates the ferroptosis to promote thyroid cancer malignancy by facilitating GPX4 via elevating SIRT6."ENVIRONMENTAL TOXICOLOGY.2023 Oct;: 11. [IF=3.3] Zhang Xueyan et al."A (Traditional Chinese Medicine) TCM-Inspired Doxorubicin Resistance Reversing Strategy: Preparation, Characterization, and Application of a Co-loaded pH-Sensitive Liposome."AAPS PHARMSCITECH.10.1208/s12249-023-02630-8 10. [IF=4.6] Minghui Liu et al."Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec498 Residue of Cytosolic Selenoprotein Thioredoxin Reductase."MOLECULES.10.3390/mol 9. [IF=6.706] Peiwen Zhang et al."n-3 PUFA Promotes Ferroptosis in PCOS GCs by Inhibiting YAP1 through Activation of the Hippo Pathway."Nutrients.2023 Jan;15(8):1927 8. [IF=6.51] Yang Wang et al."Local Delivery of Artesunate Dimer Liposomes Incorporated Injectable Hydrogel for H2O2 and pH-Independent Chemodynamic Therapy."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2023 Mar;:122822 7. [IF=17.694] Fang Fang et al."Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis."Nature Communications.2023 Mar;14(1):1-14 6. [IF=2.893] Yingxi Wang et al."Relationship Between ACSL4-Mediated Ferroptosis and Chronic Obstructive Pulmonary Disease."International Journal of Chronic Obstructive Pulmonary Disease. 5. [IF=4.831] Ying Lan et al."Polysiloxane-based hyperbranched fluorescent probe for dynamic visualization of HClO in lysosomes and vivo."SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY.2023 Jun;294:122527 4. [IF=6.313] Yijia Yang et al."Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin."Antioxidants-Basel. 2022 Apr;11(4):710 3. [IF=3.59] Jie Zhao et al."Activation of SSAT1/ALOX15 Axis Aggravates Cerebral Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis."Neuroscience. 2022 Mar;485:78 2. [IF=8.183] Zhicheng Zhang et al."Versatile iron-vitamin K 3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy."Nano Res. 2021 Jul;14(7):2398-2409 1. [IF=11.556] Junjie Ren et al."Ultrasound (US)-activated redox dyshomeostasis therapy reinforced by immunogenic cell death (ICD) through a mitochondrial targeting liposomal nanosystem."Theranostics. 2021; 11(19): 9470–9491