| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S81311-5mg |
≥97% | ￥720.00 | 10 | - | - | - |
|
S81311-10mg |
≥97% | ￥1230.00 | 7 | - | - | - |
|
S81311-25mg |
≥97% | ￥2670.00 | 3 | - | - | - |
|
S81311-50mg |
≥97% | ￥4325.00 | 1 | - | - | - |
|
S81311-100mg |
≥97% | ￥7200.00 | 1 | - | - | - |
|
PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.
| 产品描述： | PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | Raf | ||||||||||||||||||||
| 体内研究： | PLX7904 inhibits the COLO205 xenograft growth in eight mice per group | ||||||||||||||||||||
| 细胞实验： | Cells are treated with PB04(PLX7904) at different concentrations (0, 0.05, 0.1, 1, 5 μM) for 24 h. Cells are lysed and analyzed by Western blotting with phospho-MEK1/2, total MEK1/2, phospho-ERK1/2 and total ERK1/2 antibodies. (Only for Reference) | ||||||||||||||||||||
| 参考文献： | 1. Zhang C, et al. Nature. 2015, 526(7574):583-586. 2. Le K, et al. Pigment Cell Melanoma Res. 2013, 26(4):509-517. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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