| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S81552-1mg买3赠1 |
99.80% | ￥232.00 |
4 | - | - | - | - |
|
S81552-5mg促销 |
99.80% | ￥424.00 ￥339.00 |
7 | - | - | - | - |
|
S81552-10mg促销 |
99.80% | ￥720.00 ￥576.00 |
5 | - | - | - | - |
|
S81552-25mg促销 |
99.80% | ￥1440.00 ￥1150.00 |
3 | - | - | - | - |
|
S81552-50mg促销 |
≥99% | ￥2510.00 ￥2000.00 |
货期：2-3天 | - | - | - | - |
|
S81552-100mg |
≥99% | ￥4000.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | BI-78D3 functions as a substrate competitive inhibitor of JNK, inhibit the JNK kinase activity (IC50=280 nM). | ||||||||||||||||||||
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| 靶点： | JNK:280 nM (IC50);JNK | ||||||||||||||||||||
| 体内研究： | The link between ConA-induced liver failure, TNF receptor signaling, and JNK function has been established by studies employing JNK1-/- and JNK2-/- mice. For this analysis, insulin insensitive mice are injected only once with 25 mg/kg BI-78D3, 30 min before insulin injection. The effect of insulin on blood glucose levels is then measured. BI-78D3 results in a statistically significant reduction in blood glucose levels as compared with the vehicle control. Thus, the ability of BI-78D3 to abrogate ConA-induced liver damage and restore insulin sensitivity is consistent with its proposed function as an effective JNK inhibitor. Liquid chromatography/mass spectrometry bio-availability analysis demonstrates that BI-78D3 has favorable microsome and plasma stability (T1/2=54 min) | ||||||||||||||||||||
| 参考文献： | 1. Stebbins JL et al. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A, 2008 Oct 28, 105(43):16809-13. | ||||||||||||||||||||
| 溶解性： | DMSO : 100 mg/mL (263.59 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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