货号	规格	价格	上海	北京	珠海	重庆	武汉
S82881-5mg	≥98%	￥1150.00 S82881-5mg ￥1150.00 3-5天	0 货期：3-5天	-	-	-	-
S82881-10mg	≥98%	￥1890.00 S82881-10mg ￥1890.00 3-5天	0 货期：3-5天	-	-	-	-
S82881-25mg	≥98%	￥3200.00 S82881-25mg ￥3200.00 3-5天	0 货期：3-5天	-	-	-	-

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产品描述：

GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM

靶点：

IC50: 53.6 nM (EBI2);Others

体外研究：

GSK682753 is a selective and highly potent inverse agonist for murine as well as human EBI2 with inhibition of G protein-dependent signals as well as signals that are probably G protein-independent. In cAMP-response element-binding protein-based reporter and guanosine5'-3-O-(thio)-triphosphate (GTPγS) binding assays, the potency of this compound is 2.6-53.6 nM, and its inhibitory efficacy is 75%. GSK682753A dose-dependently inhibits EBI2 with an IC50of 53.6 nM. GSK682753A inhibits ERK phosphorylation, GTPγS binding, and cAMP-response element-binding protein activation with similar potency

参考文献：

1. Benned-Jensen T, et al. Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem. 2011 Aug 19;286(33):29292-302.

溶解性：

soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.084 ml	10.421 ml	20.843 ml
5 mM	0.417 ml	2.084 ml	4.169 ml
10 mM	0.208 ml	1.042 ml	2.084 ml
50 mM	0.042 ml	0.208 ml	0.417 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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