货号	规格	价格	上海	北京	珠海	重庆	武汉
S83548-5mg	≥98%	￥720.00 S83548-5mg ￥720.00 现货	8 8	-	-	-	-
S83548-25mg	≥98%	￥3000.00 S83548-25mg ￥3000.00 现货	3 3	-	-	-	-
S83548-50mg	≥98%	￥4490.00 S83548-50mg ￥4490.00 现货	1 1	-	-	-	-
S83548-100mg	≥98%	￥6800.00 S83548-100mg ￥6800.00 3-5天	0 0 货期：3-5天	-	-	-	-

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产品描述：

Asimadoline (EMD-61753) is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS)

靶点：

IC50: 5.6 nM (guinea pig κ opioid), 1.2 nM (human recombinant κ opioid);OpioidReceptor

体内研究：

Asimadoline (EMD-61753; 1, 5, 15 mg/kg; s.c.) acutely ameliorates both formalin-evoked hyperalgesia and tactile allodynia in diabetic rats. The absorption rate following oral administration is 80% in rats and >90% in dogs and monkeys. The metabolism of Asimadoline is rapid and appears similar in animals and man. Asimadoline has peripheral anti-inflammatory actions that are partly mediated through increase in joint fluid substance P levels

参考文献：

1. Camilleri M, et al. Asimadoline, a κ-Opioid Agonist, and Visceral Sensation. Neurogastroenterol Motil. 2008 Sep; 20(9): 971–979. 2. Binder W, et al. Involvement of substance P in the anti-inflammatory effects of the peripherally selective kappa-opioid asimadoline and the NK1 antagonist GR205171. Eur J Neurosci. 1999 Jun;11(6):2065-72. 3. C G Jolivalt, et al. Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats. Diabetologia. 2006 Nov;49(11):2775-85.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.412 ml	12.062 ml	24.123 ml
5 mM	0.482 ml	2.412 ml	4.825 ml
10 mM	0.241 ml	1.206 ml	2.412 ml
50 mM	0.048 ml	0.241 ml	0.482 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

阿西马多林

ASIMADOLINE

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)