| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S83592-5mg买3赠1 |
99.90% | ￥245.00 |
>10 | - | - | - | - |
|
S83592-10mg买3赠1 |
99.90% | ￥408.00 |
>10 | - | - | - | - |
|
S83592-50mg促销 |
99.90% | ￥1080.00 ￥864.00 |
>10 | - | - | - | - |
|
S83592-100mg促销 |
99.90% | ￥1760.00 ￥1400.00 |
>10 | - | - | - | - |
|
| 产品描述： | GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist | ||||||||||||||||||||
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| 靶点： | α7-nAChR;human α4β2:20 nM (Ki);5-HT3A Receptor:3.1 μM (IC50) | ||||||||||||||||||||
| 体内研究： | GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury | ||||||||||||||||||||
| 参考文献： | 1. Briggs CA, et al. Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav. 1997;57(1-2):231-241. 2. Zhang R, et al. N-terminal domains in mouse and human 5-hydroxytryptamine3A receptors confer partial agonist and antagonist properties to benzylidene analogs of anabaseine. J Pharmacol Exp Ther. 2006;317(3):1276-1284. 3. Mei Z, et al. α7 nAchR agonist GTS 21 reduces radiation induced lung injury. Oncol Rep. 2018;40(4):2287-2297. | ||||||||||||||||||||
| 溶解性： | H2O : 50 mg/mL (131.13 mM; Need ultrasonic) DMSO : 16.5 mg/mL (43.27 mM; Need ultrasonic and warming) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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