货号	规格	价格	上海	北京	珠海	重庆	武汉
S84218-1mg买3赠1	99.50%	￥400.00 S84218-1mg ￥400.00 现货（买3赠1）	7 7	-	-	-	-
S84218-5mg买3赠1	99.50%	￥820.00 S84218-5mg ￥820.00 现货（买3赠1）	6 6	-	-	-	-
S84218-10mg促销	99.50%	￥1140.00 ￥912.00 S84218-10mg ￥912.00 现货	6 6	-	-	-	-
S84218-25mg促销	99.50%	￥2510.00 ￥2000.00 S84218-25mg ￥2000.00 现货	5 5	-	-	-	-

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产品描述：

KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM

靶点：

Ki: 370 nM (CaMK-II)

体外研究：

After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H+, K+-ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca2+-independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93

参考文献：

1. Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep;6(9):1063-70. 2. Li J, et al. Curcumin Attenuates Retinal Vascular Leakage by Inhibiting Calcium/Calmodulin-Dependent Protein Kinase II Activity in Streptozotocin-Induced Diabetes. Cell Physiol Biochem. 2016;39(3):1196-208. 3. Mamiya N, et al. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitorKN-93. Biochem Biophys Res Commun. 1993 Sep 15;195(2):608-15. 4. Anderson ME, et al. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.86 ml	9.302 ml	18.605 ml
5 mM	0.372 ml	1.86 ml	3.721 ml
10 mM	0.186 ml	0.93 ml	1.86 ml
50 mM	0.037 ml	0.186 ml	0.372 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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计算重置

KN-93 (hydrochloride)