货号	规格	价格	上海	北京	珠海	重庆	武汉
S85016-5mg买3赠1	99.60%	￥700.00 S85016-5mg ￥700.00 现货（买3赠1）	205 0 >10	-	-	-	-
S85016-10mg买3赠1	99.60%	￥1260.00 S85016-10mg ￥1260.00 现货（买3赠1）	107 >10	-	-	-	-
S85016-25mg买3赠1	99.60%	￥2530.00 S85016-25mg ￥2530.00 现货（买3赠1）	46 >10	-	-	-	-
S85016-50mg买3赠1	99.60%	￥4060.00 S85016-50mg ￥4060.00 现货（买3赠1）	25 >10	-	-	-	-
S85016-100mg	99.60%	￥6300.00 S85016-100mg ￥6300.00 现货	15 >10	-	-	-	-

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产品描述：

LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.

靶点：

TrkB;TrkC;ERK;ERK;Trkreceptor;Akt

体外研究：

LM22B-10 exhibits maximum neurotrophic survival activity levels that are higher than those maximally achieved with BDNF (53 ± 7.2% above BDNF at 0.7 nM) and NT-3 (91 ± 8.6% above NT-3 at 0.7 nM) with an EC50 value of 200-300 nM. LM22B-10 (1000 nM) induces neurites of significantly larger average lengths, up to -40 μM. LM22B-10 (250-2000 nM) binds to TrkB-Fc and TrkC-Fc in a dose-dependent manner. LM22B-10 inhibits binding of BDNF to TrkB-expressing cells and NT-3 to TrkC-expressing cells. LM22B-10 promotes cell survival and functions preferentially through TrkB and TrkC. LM22B-10, but not BDNF or NT-3, promotes neurite outgrowth in an inhibitory environment. LM22B-10 induces patterns of Trk and downstream signaling activation that are distinct from those of BDNF and NT-3. LM22B-10 also induces TrkB, TrkC, AKT and ERK activation in hippocampal neurons in culture

体内研究：

LM22B-10 (0.5 mg/kg) activates TrkB, TrkC, AKT and ERK in C57BL/6J mice. LM22B-10 (50 mg/kg, i,p,) shows increased phosphorylation at TrkBY817 and TrkCY820. LM22B-10 activates synaptic TrkB and TrkC and increases pre- and post-synaptic proteins and spine density in aged mice

参考文献：

1. Yang T, et al. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016 Nov;110(Pt A):343-61.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.062 ml	10.309 ml	20.618 ml
5 mM	0.412 ml	2.062 ml	4.124 ml
10 mM	0.206 ml	1.031 ml	2.062 ml
50 mM	0.041 ml	0.206 ml	0.412 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=6.2] Qingqing Han et al."Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2025;73(36):22485–22501

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