| 产品描述: | LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. LTV-1 has the potential for autoimmunity treatment |
| 靶点: |
IC50: 508 nM (LYP, in T cells) |
| 体外研究: |
LTV-1 (1.25-40 μM) has no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM). Thus, LTV-1 is not cytotoxic in HeLa cells, Jurkat TAg T cells and peripheral blood mononuclear cells (PBMC). Cell Viability Assay Cell Line: HeLa cells, Jurkat TAg T cells, and PBMC Concentration: 1.25, 2.5, 5.0, 10, 20 , and 40 μM Incubation Time: 48 hours Result: Had no notable effect on cell viability (metabolic rate assay), even at the highest concentration tested (40 μM). |
| 参考文献: |
1. Vang T, et al. LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol. 2012 Mar 18;8(5):437-446. |
| 溶解性: |
Soluble in DMSO |
| 保存条件: |
-20℃ |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.116 ml |
10.582 ml |
21.163 ml |
| 5 mM |
0.423 ml |
2.116 ml |
4.233 ml |
| 10 mM |
0.212 ml |
1.058 ml |
2.116 ml |
| 50 mM |
0.042 ml |
0.212 ml |
0.423 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |