| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85076-1mg促销 |
≥98% | ￥360.00 ￥280.00 |
10 | - | - | - | - |
|
S85076-5mg促销 |
≥98% | ￥940.00 ￥750.00 |
10 | - | - | - | - |
|
S85076-10mg促销 |
≥98% | ￥1500.00 ￥1190.00 |
7 | - | - | - | - |
|
S85076-25mg促销 |
≥98% | ￥2800.00 ￥2230.00 |
3 | - | - | - | - |
|
S85076-50mg促销 |
≥98% | ￥4200.00 ￥3350.00 |
1 | - | - | - | - |
|
S85076-100mg促销 |
≥98% | ￥5900.00 ￥4710.00 |
1 | - | - | - | - |
|
| 产品描述： | Roluperidone (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively). | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | 5-HT2A Receptor:7.53 nM (Ki);Sigma-2 Receptor:8.19 nM (Ki);Sigmareceptor;5-HTReceptor | ||||||||||||||||||||
| 体外研究： | Roluperidone (CYR-101) also shows binding affinity for α1-adrenergic receptors but low or no affinity for muscarinic, cholinergic, and histaminergic receptors. Although Roluperidone (CYR-101) has no affinities for pre- or postsynaptic dopaminergic receptors, it is probable that sigma-2 receptors are implicated in the modulation of dopamine and glutamatergic pathways, as well as in calcium neuronal modulation | ||||||||||||||||||||
| 参考文献： | 1. Davidson M, et al. Efficacy and Safety of MIN-101: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial of a New Drug in Development for the Treatment of Negative Symptoms in Schizophrenia. Am J Psychiatry. 2017 Jul 28:appiajp201717010122. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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