| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S85507-5mg买3赠1 |
99.40% | ￥544.00 |
10 | - | - | - | - |
|
S85507-10mg买3赠1 |
99.40% | ￥860.00 |
9 | - | - | - | - |
|
S85507-50mg买3赠1 |
99.40% | ￥2100.00 |
5 | - | - | - | - |
|
S85507-100mg买3赠1 |
99.40% | ￥3400.00 |
5 | - | - | - | - |
|
| 产品描述： | ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM. | ||||||||||||||||||||
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| 靶点： | IC50: 7 μM (MIF) | ||||||||||||||||||||
| 体内研究： | ISO-1 (injected intraperitoneally; 3.5-35 mg/kg; twice daily; 2 weeks) improves the survival rate from lethal endotoxemia and shows the anti-inflammatory effect. ISO-1 (intraperitoneal injection; 35 mg/kg; twice daily; 3 days) causes a significant reduction in average implant size and decreases Flk1 expression in implants | ||||||||||||||||||||
| 参考文献： | 1. Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82. 2. Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280(44):36541-4. 3. Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3(3):135-142. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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