| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S86045-5mg促销 |
99.80% | ￥78.00 ￥62.00 |
9 | - | - | - | - |
|
S86045-10mg促销 |
99.80% | ￥140.00 ￥112.00 |
>10 | - | - | - | - |
|
S86045-25mg促销 |
99.80% | ￥270.00 ￥216.00 |
1 | - | - | - | - |
|
S86045-50mg促销 |
99.80% | ￥500.00 ￥400.00 |
>10 | - | - | - | - |
|
| 产品描述： | WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM). | ||||||||||||||||||||
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| 靶点： | 5-HT Receptor;5-HTReceptor | ||||||||||||||||||||
| 体内研究： | WAY 100635所产生的拮抗作用通过增加5-HT的浓度至300 μM,IC50为0.95 nM | ||||||||||||||||||||
| 细胞实验： | Extracellular recordings are made with glass microelectrodes filled with 2 M NaC1 (12 MΩ-15 MΩ). Cells are identified as 5-HT neurons according to the following criteria: biphasic action potentials of 2 msec to 3 msec in duration, slow (0.5 Hz - 2.0 Hz) and regular pattern of discharge. Firing is evoked in the otherwise silent neurons by adding the alpha-l adrenergic agonist phenylephrine (3 μM) to the superfusing ACSF. Baseline activity is recorded for at least 10 minutes before application of the different drugs. The electric signals are fed into a high-input impedance amplifier, an oscilloscope and an electronic ratemeter triggered by individual action potentials connected to an A/D converter and a personal computer. Using dedicated software, the integrated firing rate is recorded, computed and displayed on a chart recorder as consecutive 10-sec samples. The effects of agonists are evaluated by comparing the mean discharge frequency recorded during the 2 minutes that preceded WAY 100635 application with th | ||||||||||||||||||||
| 参考文献： | 1.Corradetti R, et al. J Pharmacol Exp Ther. 1996, 278(2), 679-688. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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