货号	规格	价格	上海	北京	珠海	重庆	武汉
S86071-5mg买3赠1	99.50%	￥400.00 S86071-5mg ￥400.00 现货（买3赠1）	3 3	-	-	-	-
S86071-10mg买3赠1	99.50%	￥660.00 S86071-10mg ￥660.00 现货（买3赠1）	5 5	-	-	-	-
S86071-25mg买3赠1	99.50%	￥1360.00 S86071-25mg ￥1360.00 现货（买3赠1）	4 4	-	-	-	-
S86071-50mg买3赠1	≥98%	￥2460.00 S86071-50mg ￥2460.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S86071-100mg	≥98%	￥3940.00 S86071-100mg ￥3940.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties.

靶点：

Dehydrogenase

体外研究：

Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells

体内研究：

R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice

参考文献：

1. Jin L, et al. Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 2015 Feb 9;27(2):257-70.

溶解性：

Soluble in DMSO、Ethanol、DMF

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.784 ml	18.92 ml	37.839 ml
5 mM	0.757 ml	3.784 ml	7.568 ml
10 mM	0.378 ml	1.892 ml	3.784 ml
50 mM	0.076 ml	0.378 ml	0.757 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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