品牌	货号	产品规格	价格(RMB)	库存（上海）	北京	武汉	南京
源叶(MedMol)	S86548-1mg	98%	￥210.80元	5	-	-	-
源叶(MedMol)	S86548-2mg	98%	￥380.80元	5	-	-	-
源叶(MedMol)	S86548-5mg	98%	￥680.00元	5	-	-	-
源叶(MedMol)	S86548-10mg	98%	￥1156.00元	6	-	-	-
源叶(MedMol)	S86548-25mg	98%	￥1600.00元	4	-	-	-
源叶(MedMol)	S86548-50mg	98%	￥2750.00元	预计交期：2-3天	-	-	-
源叶(MedMol)	S86548-100mg	98%	￥4000.00元	预计交期：2-3天	-	-	-

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产品介绍

TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM

产品描述： TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM

靶点： IC50: 40 nM (recombinant SHP-1);Phosphatase;GlucocorticoidReceptor

体外研究：
SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ+ cells and induces IFNγ+ cells in human peripheral blood

体内研究：
TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ+ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent

参考文献：
1. Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36.

溶解性： soluble in DMSO

保存条件： -20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.951 ml	19.757 ml	39.513 ml
5 mM	0.79 ml	3.951 ml	7.903 ml
10 mM	0.395 ml	1.976 ml	3.951 ml
50 mM	0.079 ml	0.395 ml	0.79 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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