| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S86548-1mg |
98.7% | ￥210.80 | 5 | - | - | - |
|
S86548-2mg |
98.7% | ￥380.80 | 5 | - | - | - |
|
S86548-5mg |
98.7% | ￥680.00 | 5 | - | - | - |
|
S86548-10mg |
98.7% | ￥1156.00 | 6 | - | - | - |
|
S86548-25mg |
98.7% | ￥1600.00 | 4 | - | - | - |
|
S86548-50mg |
≥98% | ￥2750.00 | 货期：2-3天 | - | - | - |
|
S86548-100mg |
≥98% | ￥4000.00 | 货期：2-3天 | - | - | - |
|
TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM
| 产品描述： | TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM | ||||||||||||||||||||
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| 靶点： | IC50: 40 nM (recombinant SHP-1);Phosphatase;GlucocorticoidReceptor | ||||||||||||||||||||
| 体外研究： | SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ+ cells and induces IFNγ+ cells in human peripheral blood | ||||||||||||||||||||
| 体内研究： | TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ+ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent | ||||||||||||||||||||
| 参考文献： | 1. Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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