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FMK,不可逆核糖体S6激酶1/2抑制剂

    
≥98%

FMK

源叶(MedMol)
S86609 一键复制产品信息
821794-92-7
C18H19FN4O2
342.37
Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro-;FMK
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S86609-1mg促销
≥98%

¥456.00 ¥410.00

10 - - - -
S86609-5mg促销
≥98%

¥1850.00 ¥1660.00

9 - - - -
S86609-10mg促销
≥98%

¥2780.00 ¥2500.00

6 - - - -
S86609-25mg促销
≥98%

¥4860.00 ¥4380.00

2 - - - -
S86609-50mg促销
≥98%

¥6420.00 ¥5780.00

2 - - - -
S86609-100mg促销
≥98%

¥10100.00 ¥9170.00

1 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: FMK is an irreversible inhibitor of RSK2 kinase.
靶点: S6 Kinase;S6Kinase
细胞实验: RSK2 expressing Ba/F3 cell lines are generated by retroviral transduction as described by using Ba/F3 cells stably expressing FGFR3 TDII with pMSCV-puro plasmids encoding myc-tagged RSK2 variants, followed by antibiotic selection. For cell viability assays, 1×10^5 Ba/F3 cells stably expressing FGFR3 are cultured in 24-well plates with media containing increasing concentrations of FMK, acidic FGF (10 nM), and heparin (30 μg/mL) in the absence of IL-3. The relative cell viability at each experimental time point is determined by using the Celltiter96AQueous One solution proliferation kit
参考文献: 1. Bain J, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. 2. Cuello F, et al. Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation. 3. Kang S, et al. FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell. 2007 Sep;12(3):187-9.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.921 ml 14.604 ml 29.208 ml
5 mM 0.584 ml 2.921 ml 5.842 ml
10 mM 0.292 ml 1.46 ml 2.921 ml
50 mM 0.058 ml 0.292 ml 0.584 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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