| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S86609-1mg促销 |
≥98% | ￥456.00 ￥410.00 |
10 | - | - | - | - |
|
S86609-5mg促销 |
≥98% | ￥1850.00 ￥1660.00 |
9 | - | - | - | - |
|
S86609-10mg促销 |
≥98% | ￥2780.00 ￥2500.00 |
6 | - | - | - | - |
|
S86609-25mg促销 |
≥98% | ￥4860.00 ￥4380.00 |
2 | - | - | - | - |
|
S86609-50mg促销 |
≥98% | ￥6420.00 ￥5780.00 |
2 | - | - | - | - |
|
S86609-100mg促销 |
≥98% | ￥10100.00 ￥9170.00 |
1 | - | - | - | - |
|
| 产品描述： | FMK is an irreversible inhibitor of RSK2 kinase. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | S6 Kinase;S6Kinase | ||||||||||||||||||||
| 细胞实验： | RSK2 expressing Ba/F3 cell lines are generated by retroviral transduction as described by using Ba/F3 cells stably expressing FGFR3 TDII with pMSCV-puro plasmids encoding myc-tagged RSK2 variants, followed by antibiotic selection. For cell viability assays, 1×10^5 Ba/F3 cells stably expressing FGFR3 are cultured in 24-well plates with media containing increasing concentrations of FMK, acidic FGF (10 nM), and heparin (30 μg/mL) in the absence of IL-3. The relative cell viability at each experimental time point is determined by using the Celltiter96AQueous One solution proliferation kit | ||||||||||||||||||||
| 参考文献： | 1. Bain J, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. 2. Cuello F, et al. Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk on responses to alpha1-adrenergic stimulation. 3. Kang S, et al. FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway. Cancer Cell. 2007 Sep;12(3):187-9. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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