货号	规格	价格	上海	北京	珠海	重庆	武汉
S86919-5mg买3赠1	96.80%	￥830.00 S86919-5mg ￥830.00 现货（买3赠1）	6 6	-	-	-	-
S86919-10mg买3赠1	96.80%	￥1500.00 S86919-10mg ￥1500.00 现货（买3赠1）	7 7	-	-	-	-
S86919-25mg买3赠1	96.80%	￥3000.00 S86919-25mg ￥3000.00 现货（买3赠1）	7 7	-	-	-	-
S86919-100mg	96.80%	￥9180.00 S86919-100mg ￥9180.00 现货	1 1	-	-	-	-

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产品描述：

Tecovirimat is a core protein cysteine protease inhibitor potentially for treatment of smallpox infection.Tecovirimat is a novel antiviral potent and selective activity against multiple orthopoxviruses (EC50: about 10 nM). that inhibits the egress of orthopoxviruses by targeting viral p37 protein orthologs.Tecovirimat has shown efficacy in all small animal and nonhuman primate prophylaxis and therapeutic efficacy models of poxvirus-induced disease tested to date.

靶点：

Cysteine Protease

体内研究：

ST-246 administered once daily by oral gavage to mice infected intranasally with CV beginning 4 h or delayed until 72 h postinoculation was highly effective when given for a 14-day duration using 100, 30, or 10 mg/kg of body weight.?When 100 mg/kg of ST-246 was administered to VV-infected mice, a duration of 5 days was sufficient to significantly reduce mortality even when treatment was delayed 24 h postinoculation.?Viral replication in liver, spleen, and kidney, but not lung, of CV- or VV-infected mice was reduced by ST-246 compared to levels for vehicle-treated mice.When 100 mg/kg of ST-246 was given once daily to mice infected by the intranasal route with ECTV, treatment for 10 days prevented mortality even when treatment was delayed up to 72 h after viral inoculation.?Viral replication in target organs of ECTV-infected mice was also reduced

参考文献：

1.Quenelle DC, et al. Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice. Antimicrob Agents Chemother. 2007 Feb;51(2):689-95. 2.Yang G, et al. An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge. J Virol. 2005 Oct;79(20):13139-49.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.657 ml	13.286 ml	26.572 ml
5 mM	0.531 ml	2.657 ml	5.314 ml
10 mM	0.266 ml	1.329 ml	2.657 ml
50 mM	0.053 ml	0.266 ml	0.531 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

ST 246