| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S87089-2mg买3赠1 |
99.60% | ￥180.00 |
5 | - | - | - | - |
|
S87089-5mg买3赠1 |
99.60% | ￥350.00 |
6 | - | - | - | - |
|
S87089-10mg促销 |
99.60% | ￥590.00 ￥472.00 |
6 | - | - | - | - |
|
S87089-25mg促销 |
≥99% | ￥1160.00 ￥928.00 |
货期：2-3天 | - | - | - | - |
|
S87089-50mg促销 |
≥99% | ￥2080.00 ￥1660.00 |
货期：2-3天 | - | - | - | - |
|
S87089-100mg促销 |
≥99% | ￥2800.00 ￥2240.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM. IC50 value: 450 nM (Kd) Target: WDR5 in vitro: WDR5-0103 inhibits MLL catalytic activity with an IC50 value of 39±10 μM. An increase in MLL complex concentration resulted in proportional increase in IC50 values for WDR5-0103 (83±10 and 280±12 μM at concentrations of 500 and 1000 nM of the core trimeric MLL complex respectively). These data are consistent with a mechanism of action in which WDR5-0103 antagonizes the interaction of WDR5 with MLL by competing with MLL for their mutual binding site on WDR5. | ||||||||||||||||||||
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| 靶点： | Histone Methyltransferase;JAK | ||||||||||||||||||||
| 体内研究： | WDR5-0103（2.5 mg/kg；腹腔注射；每天 1 次；给药 3 天）在 P301S 转基因 Tau 小鼠中，能降低 H3K4me3水平，改善认知缺陷并恢复突触功能。 WDR5-0103（2.5 mg/kg；腹腔注射；3 次）在 5xFAD 小鼠中，能降低前额叶皮质 H3K4me3水平，改善认知功能。 |
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| 参考文献： | 1. Senisterra G, et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J. 2013 Jan 1;449(1):151-159 | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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