货号	规格	价格	上海	北京	珠海	重庆	武汉
S87607-5mg促销	97%	￥899.00 ￥809.00 S87607-5mg ￥809.00 现货	1 1	-	-	-	-
S87607-10mg促销	97%	￥1700.00 ￥1530.00 S87607-10mg ￥1530.00 现货	2 0 2	-	-	-	-
S87607-25mg促销	97%	￥3590.00 ￥3230.00 S87607-25mg ￥3230.00 现货	3 3	-	-	-	-
S87607-50mg促销	97%	￥5750.00 ￥5180.00 S87607-50mg ￥5180.00 现货	3 3	-	-	-	-
S87607-100mg促销	97%	￥8990.00 ￥8090.00 S87607-100mg ￥8090.00 现货	3 3	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).

靶点：

IC50: 975 nM (IBa);CalciumChannel; PPAR

体外研究：

(R)-(+)-Bay-K-8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist. Each optical isomer possesses opposite effects on IBa, (R)-(+)-Bay-K-8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) is applied, IBa is suppressed to 71±10% of control. In the presence of (R)-(+)-Bay-K-8644IBa[1]. (R)-(+)-Bay-K-8644 is a calcium channel inhibitor

参考文献：

1. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15. 2. Sidaway P, et al. L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle. PLoS One. 2014 Apr 3;9(4):e93803.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.807 ml	14.033 ml	28.067 ml
5 mM	0.561 ml	2.807 ml	5.613 ml
10 mM	0.281 ml	1.403 ml	2.807 ml
50 mM	0.056 ml	0.281 ml	0.561 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

(R)-(+)-Bay K 8644

Bay-K-8644 ((R)-(+)-)

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)