货号	规格	价格	上海	北京	珠海	重庆	武汉
S87736-5mg买3赠1	99.20%	￥310.00 S87736-5mg ￥310.00 现货（买3赠1）	5 5	-	-	-	-
S87736-10mg买3赠1	99.20%	￥544.00 S87736-10mg ￥544.00 现货（买3赠1）	5 5	-	-	-	-
S87736-25mg买3赠1	99.20%	￥770.00 S87736-25mg ￥770.00 现货（买3赠1）	5 5	-	-	-	-
S87736-100mg促销	99.20%	￥1150.00 ￥920.00 S87736-100mg ￥920.00 现货	3 3	-	-	-	-

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产品描述：

DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.

靶点：

Nur77

体外研究：

DIM-C-pPhOCH3 decreases survival and induces apoptosis in RKO colon cancer cells, and this is accompanied by induction of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) protein. DIM-C-pPhOCH3 also induces Nur77-independent apoptosis. DIM-C-pPhOCH3 (10 μM) inhibits cell growth after treatment for 24, 48, or 72 h, and the maximum inhibitory response is observed after 72 h, where there is considerable cell detachment and dead cells. The growth-inhibitory effects observed for DIM-C-pPhOCH3 after 72 h are also accompanied by several markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8. PARP cleavage is also observed after treatment of RKO cells for 48 h with DIM-C-pPhOCH3

体内研究：

DIM-C-pPhOCH3 (25 mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH3 (25 mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH3 significantly decreases tumor volumes and final tumor weights compared with corn oil controls

参考文献：

1. Cho SD, et al. Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Res. 2007 Jan 15;67(2):674-83.

溶解性：

Soluble in DMSO

保存条件：

2-8°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.837 ml	14.187 ml	28.375 ml
5 mM	0.567 ml	2.837 ml	5.675 ml
10 mM	0.284 ml	1.419 ml	2.837 ml
50 mM	0.057 ml	0.284 ml	0.567 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

DIM-C-PPHOCH3

3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)