货号	规格	价格	上海	北京	珠海	重庆	武汉
S87821-2mg买3赠1	99.50%	￥650.00 S87821-2mg ￥650.00 现货（买3赠1）	5 5	-	-	-	-
S87821-5mg买3赠1	99.50%	￥880.00 S87821-5mg ￥880.00 现货（买3赠1）	7 7	-	-	-	-
S87821-10mg买3赠1	99.50%	￥1420.00 S87821-10mg ￥1420.00 现货（买3赠1）	6 6	-	-	-	-
S87821-25mg买3赠1	99.50%	￥2920.00 S87821-25mg ￥2920.00 现货（买3赠1）	2 2	-	-	-	-
S87821-50mg买3赠1	≥98%	￥4350.00 S87821-50mg ￥4350.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia

靶点：

p38α:101 nM (Ki);p38MAPK; Autophagy

体内研究：

MW-150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice. Animal Model: APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta) Dosage: 2.5 mg/kg Administration: Oral daily; 3-4 months (until cognitive impairment is present) Result: Improved the Tg mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.

参考文献：

1. Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.621 ml	13.107 ml	26.214 ml
5 mM	0.524 ml	2.621 ml	5.243 ml
10 mM	0.262 ml	1.311 ml	2.621 ml
50 mM	0.052 ml	0.262 ml	0.524 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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