货号	规格	价格	上海	北京	珠海	重庆	武汉
S87841-2mg买3赠1	99.50%	￥200.00 S87841-2mg ￥200.00 现货（买3赠1）	4 4	-	-	-	-
S87841-5mg买3赠1	99.50%	￥300.00 S87841-5mg ￥300.00 现货（买3赠1）	6 6	-	-	-	-
S87841-10mg买3赠1	99.50%	￥450.00 S87841-10mg ￥450.00 现货（买3赠1）	6 6	-	-	-	-
S87841-25mg买3赠1	99.50%	￥810.00 S87841-25mg ￥810.00 现货（买3赠1）	6 6	-	-	-	-
S87841-50mg	≥98%	￥1390.00 S87841-50mg ￥1390.00 2-3天	0 货期：2-3天	-	-	-	-
S87841-100mg	≥98%	￥2360.00 S87841-100mg ￥2360.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

Aftin-4 is an Amyloid-β42 (Aβ42) inducer

靶点：

Amyloid-β;BetaAmyloid; Gamma-secretase

体外研究：

Aftin-4 selectively and potently increases Aβ1-42 in N2a cells, primary neurons, and brain lysates, with an EC50 value around 30 μM

体内研究：

Aftin-4 increases Aβ1-42 levels in vivo in mice and provokes rapidly a sustained toxicity highly reminiscent of Alzheimer’s disease (AD). Aftin-4 is administered at increasing doses, between 3 and 20 nmol/mouse, into the lateral ventricle and animals are sacrificed at various time points, between 3 to 14 days after injection. The hippocampus is dissected out the contents in Aβ1-40 or Aβ1-42 is determined using a mouse ELISA assay. Aftin-4 dose-dependently and significantly increases Aβ1-42 content, up to +216% at the highest dose tested

参考文献：

1. Meunier J, et al. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative. J Alzheimers Dis. 2015;44(2):507-24.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.714 ml	13.569 ml	27.139 ml
5 mM	0.543 ml	2.714 ml	5.428 ml
10 mM	0.271 ml	1.357 ml	2.714 ml
50 mM	0.054 ml	0.271 ml	0.543 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置