货号	规格	价格	上海	北京	珠海	重庆	武汉
S87875-5mg	99.80%	￥220.00 S87875-5mg ￥220.00 现货	5 5	-	-	-	-
S87875-10mg	99.80%	￥330.00 S87875-10mg ￥330.00 现货	7 7	-	-	-	-
S87875-25mg	99.80%	￥760.00 S87875-25mg ￥760.00 现货	6 6	-	-	-	-
S87875-100mg	≥98%	￥2190.00 S87875-100mg ￥2190.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Alsterpaullone (9-Nitropaullone) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to GSK-3alpha/GSK-3beta with IC50s of both 4 nM. Alsterpaullone has antitumor activity, and possesses potential for the study in neurodegenerative and proliferative disorders. Alsterpaullone induces apoptosis in leukemia cell line

靶点：

Cdk1/cyclin B:35 nM (IC50);cdk2/cyclin A:15 nM (IC50);CDK2/Cyc E:200 nM (IC50);CDK5/p35:40 nM (IC50);GSK-3α:4 (IC50);GSK-3β:4 nM (IC50)

体内研究：

Alsterpaullone (30 mg/kg, s.c., daily for 2 weeks) reduces tumor growth and increases survival in medulloblastoma xenografts. Animal Model: 5-6 week old athymic nude mice Dosage: 30 mg/kg Administration: Subcutaneous injections, daily for 2 weeks Result: Antitumor effect in Group 3 medulloblastomas.

参考文献：

1. Leost M, et al. Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. Eur J Biochem. 2000 Oct;267(19):5983-94. 2. Lahusen T, et al. Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Mol Carcinog. 2003 Apr;36(4):183-94. 3. Chunying Cui, et al. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. J Anal Methods Chem. 2013;2013:602091. 4. Claudia C Faria, et al. Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma. Oncotarget. 2015 Aug 28;6(25):21718-29.

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.41 ml	17.049 ml	34.097 ml
5 mM	0.682 ml	3.41 ml	6.819 ml
10 mM	0.341 ml	1.705 ml	3.41 ml
50 mM	0.068 ml	0.341 ml	0.682 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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