| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88281-5mg买3赠1 |
99.00% | ￥220.00 |
6 | - | - | - | - |
|
S88281-10mg买3赠1 |
99.00% | ￥420.00 |
7 | - | - | - | - |
|
S88281-25mg买3赠1 |
99.00% | ￥790.00 |
5 | - | - | - | - |
|
S88281-50mg |
≥98% | ￥1290.00 |
货期：2-3天 | - | - | - | - |
|
S88281-100mg |
≥98% | ￥2390.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | D159687 is a selective PDE4D inhibitor | ||||||||||||||||||||
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| 靶点： | PDE4D;PDE | ||||||||||||||||||||
| 体外研究： | D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM. Western Blot Analysis Cell Line: HT-22 (mouse hippocampal cell line) Concentration: 1 μM Incubation Time: 0, 1, 3, 6, 12, 24 hours Result: Induced a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. Western Blot Analysis Cell Line: HT-22 (mouse hippocampal cell line) Concentration: 0.01 μM, 0.1 μM, 1 μM Incubation Time: 6 hours Result: CREB phosphorylation was optimal at 1 μM. | ||||||||||||||||||||
| 体内研究： | D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques. Animal Model: Female Cynomolgus macaques (4–6 year old) Dosage: 0.05, 0.5, 5 mg/kg Administration: Oral daily for a week Result: A potential recruitment or enhancement of synaptic function with increased task difficulty. | ||||||||||||||||||||
| 参考文献： | 1. Zhang C, et al. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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