| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S88534-1mg买3赠1 |
98.00% | ￥220.00 |
4 | - | - | - | - |
|
S88534-5mg买3赠1 |
98.00% | ￥390.00 |
5 | - | - | - | - |
|
S88534-10mg买3赠1 |
98.00% | ￥580.00 |
5 | - | - | - | - |
|
S88534-25mg买3赠1 |
98.00% | ￥920.00 |
5 | - | - | - | - |
|
S88534-50mg买3赠1 |
≥98% | ￥1380.00 |
货期：2-3天 | - | - | - | - |
|
S88534-100mg |
≥98% | ￥2070.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.5 µM. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | IC50: 2.5 µM (PHGDH);Dehydrogenase; FLT; TAMReceptor | ||||||||||||||||||||
| 体内研究： | NCT-503 exhibits favorable absorption, distribution, metabolism and excretion (ADME) properties. NCT-503 has good exposure, half-life (2.5 hr) and Cmax (20 µM in plasma) following intraperitoneal administration with significant partitioning into the liver and brain. NCT-503 treatment reduces the growth and weight of PHGDH-dependent MDA-MB-468 xenografts but does not affect the growth or weight of PHGDH-independent MDA-MB-231 xenografts | ||||||||||||||||||||
| 参考文献： | 1. Pacold ME, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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