货号	规格	价格	上海	北京	珠海	重庆	武汉
S88614-5mg买3赠1	98.80%	￥310.00 S88614-5mg ￥310.00 现货（买3赠1）	6 6	-	-	-	-
S88614-10mg买3赠1	98.80%	￥510.00 S88614-10mg ￥510.00 现货（买3赠1）	6 6	-	-	-	-
S88614-25mg促销	98.80%	￥1150.00 ￥920.00 S88614-25mg ￥920.00 现货	6 6	-	-	-	-
S88614-50mg促销	98.80%	￥1810.00 ￥1440.00 S88614-50mg ￥1440.00 现货	4 4	-	-	-	-
S88614-100mg促销	≥98%	￥2880.00 ￥2300.00 S88614-100mg ￥2300.00 2-3天	0 货期：2-3天	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).

靶点：

GPRC6A;GPR; AndrogenReceptor

体外研究：

DJ-V-159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V-159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V-159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A

体内研究：

DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five

参考文献：

1. Pi M, et al. Computationally identified novel agonists for GPRC6A. PLoS One. 2018 Apr 23;13(4):e0195980.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.991 ml	9.953 ml	19.906 ml
5 mM	0.398 ml	1.991 ml	3.981 ml
10 mM	0.199 ml	0.995 ml	1.991 ml
50 mM	0.04 ml	0.199 ml	0.398 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

DJ-V159

DJ-V-159

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)