货号	规格	价格	上海	北京	珠海	重庆	武汉
S88767-5mg买3赠1	99.40%	￥310.00 S88767-5mg ￥310.00 现货（买3赠1）	7 7	-	-	-	-
S88767-10mg	99.40%	￥410.00 S88767-10mg ￥410.00 现货	6 6	-	-	-	-
S88767-50mg	≥98%	￥1190.00 S88767-50mg ￥1190.00 2-3天	0 货期：2-3天	-	-	-	-
S88767-100mg	≥98%	￥1870.00 S88767-100mg ￥1870.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. 1V209 can be conjugated with various polysaccharides to improve its water solubility, and enhance its efficacy, and maintain low toxicity

靶点：

TLR7;TLR

体外研究：

1V209 (0.1-10 μM) treatment significantly stimulates TNFα production in RAW246.7 cells. 1V209 (18 hours) treatment increases IL-6 production comparain bone marrow derived dendritic cells

体内研究：

The intravenous (IV) administration of the formulation to mice bearing 4T1 breast cancer tumors results in nanoparticle accumulation in tumors, reduction in primary tumor growth, and inhibition of lung metastases, as compared to saline-treated animals. Mice administered 1V209 experience significantly increases plasma levels of proinflammatory cytokines IL-6, IP-10, and MCP-1 at 2 h following IV administration

参考文献：

1. Battistella C, et al. Delivery of Immunotherapeutic Nanoparticles to Tumors via Enzyme-Directed Assembly. Adv Healthc Mater. 2019 Dec;8(23):e1901105. 2. Shinchi H, et al. Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides. Bioconjug Chem. 2015 Aug 19;26(8):1713-23.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.783 ml	13.914 ml	27.829 ml
5 mM	0.557 ml	2.783 ml	5.566 ml
10 mM	0.278 ml	1.391 ml	2.783 ml
50 mM	0.056 ml	0.278 ml	0.557 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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