货号	规格	价格	上海	北京	珠海	重庆	武汉
S89007-5mg买3赠1	97.60%	￥279.00 S89007-5mg ￥279.00 现货（买3赠1）	9 9	-	-	-	-
S89007-10mg买3赠1	97.60%	￥340.00 S89007-10mg ￥340.00 现货（买3赠1）	10 10	-	-	-	-
S89007-25mg买3赠1	97.60%	￥460.00 S89007-25mg ￥460.00 现货（买3赠1）	4 4	-	-	-	-
S89007-100mg买3赠1	97.60%	￥1670.00 S89007-100mg ￥1670.00 现货（买3赠1）	7 7	-	-	-	-

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产品描述：

SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines

靶点：

Apoptosis; STAT;Apoptosis; STAT

体外研究：

SC-1(1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells. SC-1(1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity in association with downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines

体内研究：

SC-1 showes efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors in vivo

细胞实验：

Incubated HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells with 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM SC-1 for 48 hours demonstrated that dose-dependent suppression of cell viability in all tested breast cancer cells. Incubated HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells with 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM SC-1 for 36 hours showed downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines and induced potent apoptotic activity

动物实验：

SC-1 (10 mg/kg; oral gavage; daily; for 28 days; Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors

参考文献：

1. Chun-Yu Liu, et al. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast Cancer Res. 2013;15(4):R63.

溶解性：

Soluble in DMSO

保存条件：

2-8°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.316 ml	11.58 ml	23.159 ml
5 mM	0.463 ml	2.316 ml	4.632 ml
10 mM	0.232 ml	1.158 ml	2.316 ml
50 mM	0.046 ml	0.232 ml	0.463 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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