货号	规格	价格	上海	北京	珠海	重庆	武汉
S89044-5mg买3赠1	99.90%	￥560.00 S89044-5mg ￥560.00 现货（买3赠1）	10 10	-	-	-	-
S89044-10mg买3赠1	99.90%	￥880.00 S89044-10mg ￥880.00 现货（买3赠1）	10 10	-	-	-	-
S89044-25mg买3赠1	≥98%	￥1760.00 S89044-25mg ￥1760.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-
S89044-100mg买3赠1	≥98%	￥4970.00 S89044-100mg ￥4970.00 2-3天（买3赠1）	0 货期：2-3天	-	-	-	-

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产品描述：

SR33805 is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca2+ channels. SR33805 can be used for the research of acute or chronic failing hearts

靶点：

L-type calcium channel:4.1 nM (EC50, in depolarized conditions);L-type calcium channel:33 nM (EC50, in polarized conditions);CalciumChannel

体内研究：

SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats. SR33805 (5 mg/kg/day; p.o. for 38 d) significantly reduces intimal hyperplasia in pigs. Animal Model: Male Wistar rats (5 weeks) are subjected to coronary artery ligature Dosage: 0.2, 2, 20 mg/kg Administration: A single i.p. injection Result: Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg.Did not affect other contractile parameters.

参考文献：

1. Romey G, et, al. Effects of two chemically related new Ca2+ channel antagonists, SR33557 (fantofarone) and SR33805, on the L-type cardiac channel. Eur J Pharmacol. 1994 Sep 22; 263(1-2): 101-5. 2. Mou YA, et, al. Beneficial effects of SR33805 in failing myocardium. Cardiovasc Res. 2011 Aug 1; 91(3): 412-9. 3. Hainaud P, et, al. The calcium inhibitor SR33805 reduces intimal formation following injury of the porcine carotid artery. Atherosclerosis. 2001 Feb 1; 154(2): 301-8.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.771 ml	8.854 ml	17.707 ml
5 mM	0.354 ml	1.771 ml	3.541 ml
10 mM	0.177 ml	0.885 ml	1.771 ml
50 mM	0.035 ml	0.177 ml	0.354 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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