iFSP1 99.90%
| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89092-5mg |
99.90% | ￥240.00 |
1 | - | - | - | - |
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S89092-10mg |
99.90% | ￥320.00 |
4 | - | - | - | - |
|
S89092-25mg |
≥98% | ￥560.00 |
货期：2-3天 | - | - | - | - |
|
S89092-100mg |
≥98% | ￥1680.00 |
货期：2-3天 | - | - | - | - |
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| 产品描述： | iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A) | ||||||||||||||||||||
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| 靶点： | EC50: 103 nM (FSP1);Ferroptosis | ||||||||||||||||||||
| 体外研究： | iFSP1 (0.001-1 μM; 24 hours) inhibits the Gpx4-knockout cell growth as a dose-dependent manner, but does not inhibit the wild type cell growth. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4- knockout cells from iFSP1-induced ferroptosis. iFSP1 (0.001-1 μM; 24 hours) is less efficient than genetic deletion of FSP1, whereas iFSP1 treatment in the FSP1-knockout background had no additive effect to RSL3-induced ferroptosis. iFSP1 (3 μM; 24 hours) treatment results in an obvious toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines. AIFM2: the flavoprotein apoptosis-inducing factor mitochondria-associated 2 is a previously unrecognized anti-ferroptotic gene. AIFM2, which is renamed ferroptosis suppressor protein 1 (FSP1) Cell Proliferation Assay Cell Line: Wild-type and Gpx4-knockout Pfa1 or HT 1080 cells overexpressing FSP1–HA Concentration: 0.001-1 μM Incubation Time: 24 hours Result: Was toxic to cells that depend solely (no GPX4 expression detectable) on FSP1 function. Cell Viability Assay Cell Line: NCl-H1437, NCl-H1437 FSP1 KO, U-373, U-373 FSP1 KO, MDA-MB-436, MDA-MB-436 FSP1 KO, SW620, SW620 FSP1 KO, MDA-MB-435S, MDA-MB-435S FSP1 KO, A549 and A549 FSP1 KO Concentration: 3 μM Incubation Time: 24 hours Result: Sensitized a variety of human cancer cell lines to the ferroptosis inducer (1S,3R)-RSL3. | ||||||||||||||||||||
| 参考文献： | 1. Doll S, et al. FSP1 is a glutathione-independent ferroptosis suppressor.Nature. 2019 Nov;575(7784):693-698. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
参考文献(3篇)
3. [IF=12.8] Zhou Zhike et al."Inhibition of RACGAP1 sensitizes triple-negative breast cancer cells to ferroptosis by regulating CPT1A-dependent fatty acid metabolism."JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH.2025 Dec;44(1):323
2. [IF=9.6] Xiaokang Zhu et al."Calcium phosphate-mineralized nanoplatform for enhanced ferroptosis and synergistic anti-PDL1 therapy in triple-negative breast cancer through multi-pathway targeting."Acta Biomaterialia.2025 Aug;:
1. [IF=9.6] Xiaokang Zhu et al."Calcium phosphate-mineralized nanoplatform for enhanced ferroptosis and synergistic anti-PDL1 therapy in triple-negative breast cancer through multi-pathway targeting."Acta Biomaterialia.2025 Aug;:
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