货号	规格	价格	上海	北京	珠海	重庆	武汉
S89110-5mg买3赠1	99.10%	￥520.00 S89110-5mg ￥520.00 现货（买3赠1）	4 4	-	-	-	-
S89110-10mg买3赠1	99.10%	￥740.00 S89110-10mg ￥740.00 现货（买3赠1）	6 6	-	-	-	-
S89110-25mg促销	99.10%	￥1330.00 ￥1060.00 S89110-25mg ￥1060.00 现货	6 6	-	-	-	-
S89110-100mg促销	≥98%	￥2620.00 ￥2090.00 S89110-100mg ￥2090.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

TTK21 is an activator of CBP/p300 histone acetyltransferase activity.

靶点：

Epigenetic Reader Domain;EpigeneticReaderDomain

体内研究：

a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjugated to glucose-based carbon nanosphere (CSP), passed the blood-brain barrier, induced no toxicity, and reached different parts of the brain.?After intraperitoneal administration in mice, CSP-TTK21 significantly acetylated histones in the hippocampus and frontal cortex.?Remarkably, CSP-TTK21 treatment promoted the formation of long and highly branched doublecortin-positive neurons in the subgranular zone of the dentate gyrus and reduced BrdU incorporation, suggesting that CBP/p300 activation favors maturation and differentiation of adult neuronal progenitors.?In addition, mRNA levels of the neuroD1 differentiation marker and BDNF, a neurotrophin required for the terminal differentiation of newly generated neurons, were both increased in the hippocampus concomitantly with an enrichment of acetylated-histone on their proximal promoter.

参考文献：

1. Chatterjee, S., Mizar, P., Cassel, R., et al. A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice. J. Neurosci. 33(26), 10698-10712 (2013).

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.795 ml	13.974 ml	27.949 ml
5 mM	0.559 ml	2.795 ml	5.59 ml
10 mM	0.279 ml	1.397 ml	2.795 ml
50 mM	0.056 ml	0.279 ml	0.559 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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