| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89174-5mg买3赠1 |
99.60% | ￥480.00 |
6 | - | - | - | - |
|
S89174-10mg买3赠1 |
99.60% | ￥784.00 |
6 | - | - | - | - |
|
S89174-25mg促销 |
99.60% | ￥1280.00 ￥1020.00 |
7 | - | - | - | - |
|
S89174-100mg促销 |
99.60% | ￥3600.00 ￥2880.00 |
6 | - | - | - | - |
|
| 产品描述： | DTHIB (Direct Targeted HSF1 InhiBitor) 是一种直接的 heat shock factor 1 (HSF1) 的选择性抑制剂，其Kd值为160 nM，用于DTHIB与HSF1 DNA结合域(DBD)的结合。DTHIB 具有强大的抗癌活性 | ||||||||||||||||||||
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| 靶点： | HSF1(Cell-free assay):160 nM(Kd);HSP | ||||||||||||||||||||
| 体外研究： | Direct Targeted HSF1 InhiBitor (DTHIB) physically engages HSF1 and selectively stimulates degradation of nuclear HSF1. DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation | ||||||||||||||||||||
| 体内研究： | DTHIB potently attenuates tumor progression in four therapy-resistant prostate cancer animal models, including an NEPC model, where it causes profound tumor regression | ||||||||||||||||||||
| 细胞实验： | Cell lines: C4-2, PC-3, BPH-1 cells Concentrations: 0.5 μM, 1.0 μM, 2.5 μM, 5 μM Incubation Time: 36-hour, 48-hour, 96-hour Method: C4-2 Scr and shHSF1 cells exposed to 36-hour treatment with 2.5 μM DTHIB are evaluated for HSF1 target gene expression by qRT-PCR | ||||||||||||||||||||
| 动物实验： | Animal Models: 6-week-old nude (nu/nu) mice; 6 week-old C57BL/6 mice Dosages: 1 mg/kg, 5 mg/kg Administration: IP | ||||||||||||||||||||
| 参考文献： | 1. Bushu Dong, et al. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Sci Transl Med. 2020 Dec 16;12(574):eabb5647. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
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营业执照(三证合一)
北京