首页
订购/客服:400-666-5481

YUM70

    
96.80%

N-[1,3-Benzodioxol-5-yl(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide

源叶(MedMol)
S89179 一键复制产品信息
423145-35-1
C21H19ClN2O4
398.84
YUM70; YUM-70; YUM 70;
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
S89179-5mg促销
96.80%

¥740.00 ¥666.00

6 2 2 - -
S89179-10mg促销
96.80%

¥1200.00 ¥1080.00

6 - - - -
S89179-25mg促销
96.80%

¥2310.00 ¥2080.00

5 - - - -
S89179-50mg促销
96.80%

¥3810.00 ¥3420.00

5 - - - -
S89179-100mg促销
96.80%

¥6180.00 ¥5560.00

5 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model
靶点: IC50: 1.5 μM (glucose-regulated protein 78);Apoptosis; GPR; HSP
体外研究: YUM70 shows selective cytotoxicity for MIA PaCa-2, PANC-1, BxPC-3 cells (IC50=2.8, 4.5, and 9.6 μM, respectively) over normal pancreatic tissue-derived HPNE cells (IC50>30 μM). YUM70 (5 μM; 24 h) induces endoplasmic reticulum (ER) stress-mediated apoptosis of MIA PaCa-2cells. Western Blot Analysis Cell Line: MIA PaCa-2, PANC-1 cells Concentration: 0.1, 1, 2.5, 5, 10 μM Incubation Time: 2, 4, 8, 24, 48 hours Result: Increased the protein levels of FAM129A, DDIT3, CHAC-1, DDIT4, UPP1, and GRP78 in a dose- and time-dependent manner.
体内研究: YUM70 (30 mg/kg; i.p. 5 days a week for 7 weeks) inhibits tumor growth in a MIA PaCa-2 xenograft model. YUM70 (15 mg/kg; i.v.) exhibits t1/2 (1.40 h), CL (724.04 mL/h/kg), and Vss (1162.73 mL/kg) in mice. YUM70 (30 mg/kg; p.o.) exhibits bioavailability (6.71%), t1/2 (2.74 h), and CL (9230.15 mL/h/kg) in mice. Animal Model: 8-week old female NCr nude mice were injected with MIA PaCa-2 cells Dosage: 30 mg/kg Administration: I.p. 5 days a week for 7 weeks Result: Observed a significant tumor growth delay with no significant change in body weight during the course of treatment.
参考文献: 1. Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020.
溶解性: Soluble  in  DMSO
保存条件: -20℃
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.507 ml 12.536 ml 25.073 ml
5 mM 0.501 ml 2.507 ml 5.015 ml
10 mM 0.251 ml 1.254 ml 2.507 ml
50 mM 0.05 ml 0.251 ml 0.501 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

如何获取质检证书(COA)?
请输入货号和一个与之匹配的批号。
例如:
批号:JS298415 货号:S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

=
×
×