| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89179-5mg促销 |
96.80% | ￥740.00 ￥666.00 |
6 | 2 | 2 | - | - |
|
S89179-10mg促销 |
96.80% | ￥1200.00 ￥1080.00 |
6 | - | - | - | - |
|
S89179-25mg促销 |
96.80% | ￥2310.00 ￥2080.00 |
5 | - | - | - | - |
|
S89179-50mg促销 |
96.80% | ￥3810.00 ￥3420.00 |
5 | - | - | - | - |
|
S89179-100mg促销 |
96.80% | ￥6180.00 ￥5560.00 |
5 | - | - | - | - |
|
| 产品描述： | YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model | ||||||||||||||||||||
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| 靶点： | IC50: 1.5 μM (glucose-regulated protein 78);Apoptosis; GPR; HSP | ||||||||||||||||||||
| 体外研究： | YUM70 shows selective cytotoxicity for MIA PaCa-2, PANC-1, BxPC-3 cells (IC50=2.8, 4.5, and 9.6 μM, respectively) over normal pancreatic tissue-derived HPNE cells (IC50>30 μM). YUM70 (5 μM; 24 h) induces endoplasmic reticulum (ER) stress-mediated apoptosis of MIA PaCa-2cells. Western Blot Analysis Cell Line: MIA PaCa-2, PANC-1 cells Concentration: 0.1, 1, 2.5, 5, 10 μM Incubation Time: 2, 4, 8, 24, 48 hours Result: Increased the protein levels of FAM129A, DDIT3, CHAC-1, DDIT4, UPP1, and GRP78 in a dose- and time-dependent manner. | ||||||||||||||||||||
| 体内研究： | YUM70 (30 mg/kg; i.p. 5 days a week for 7 weeks) inhibits tumor growth in a MIA PaCa-2 xenograft model. YUM70 (15 mg/kg; i.v.) exhibits t1/2 (1.40 h), CL (724.04 mL/h/kg), and Vss (1162.73 mL/kg) in mice. YUM70 (30 mg/kg; p.o.) exhibits bioavailability (6.71%), t1/2 (2.74 h), and CL (9230.15 mL/h/kg) in mice. Animal Model: 8-week old female NCr nude mice were injected with MIA PaCa-2 cells Dosage: 30 mg/kg Administration: I.p. 5 days a week for 7 weeks Result: Observed a significant tumor growth delay with no significant change in body weight during the course of treatment. | ||||||||||||||||||||
| 参考文献： | 1. Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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