货号	规格	价格	上海	北京	珠海	重庆	武汉
S89201-5mg买3赠1	99.60%	￥320.00 S89201-5mg ￥320.00 现货（买3赠1）	5 5	-	-	-	-
S89201-10mg买3赠1	99.60%	￥480.00 S89201-10mg ￥480.00 现货（买3赠1）	7 7	-	-	-	-
S89201-25mg买3赠1	99.60%	￥960.00 S89201-25mg ￥960.00 现货（买3赠1）	6 6	-	-	-	-
S89201-100mg	≥98%	￥1810.00 S89201-100mg ￥1810.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

BMS 191011 (BMS-A) is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke

靶点：

Potassium Channel;PotassiumChannel

体外研究：

BMS-191011 (20 or 40 µM) activates BK channels in IGR39 cells, and leads to potentiation in Panc-1 cells. Cell Viability Assay Cell Line: IGR39 and Panc-1 cells Concentration: 20 or 40 µM Incubation Time: Result: Activated BK channels in less than 50% IGR39 cells and led to less than two-fold potentiation in Panc-1 cells.Promoted the activation of a voltage-independent K+ conductance at negative voltages.

体内研究：

BMS-191011 (intravenous injection; 10-100 µg/kg; once) dilates rat retinal arterioles through activation of iberiotoxin-sensitive BK(Ca) channels in vivo. Animal Model: Male Wistar rats (8- to 10-week-old) treated with Tetrodotoxin (50 µg/kg, intravenously (i.v.)) Dosage: 10-100 µg/kg Administration: Intravenous injection; 10-100 µg/kg; once Result: Increased the diameter of retinal arterioles, showed no significant effect on mean arterial pressure and heart rate.

参考文献：

1. Romine JL, et al. 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. J Med Chem. 2007 Feb 8;50(3):528-42. 2. Asami Mori, et al. BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. Biol Pharm Bull. 2011;34(1):150-2. 3. Remigante A, et al. NS-11021 Modulates Cancer-Associated Processes Independently of BK Channels in Melanoma and Pancreatic Duct Adenocarcinoma Cell Lines. Cancers (Basel). 2021 Dec 6;13(23):6144.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.698 ml	13.488 ml	26.975 ml
5 mM	0.54 ml	2.698 ml	5.395 ml
10 mM	0.27 ml	1.349 ml	2.698 ml
50 mM	0.054 ml	0.27 ml	0.54 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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