货号	规格	价格	上海	北京	珠海	重庆	武汉
S89205-5mg	99.90%	￥192.00 S89205-5mg ￥192.00 现货	6 6	-	-	-	-
S89205-10mg	99.90%	￥340.00 S89205-10mg ￥340.00 现货	6 6	-	-	-	-
S89205-25mg	99.90%	￥710.00 S89205-25mg ￥710.00 现货	2 2	-	-	-	-
S89205-100mg	≥98%	￥1530.00 S89205-100mg ￥1530.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM

靶点：

IC50: 295 nM (STK16)

体外研究：

STK16-IN-1, which exhibits potent inhibitory activity against STK16 kinase (IC50=0.295 μM) with excellent selective across the kinome as assessed using the KinomeScanTM profiling assay. STK16-IN-1 inhibits mTOR kinase with an IC50 of 5.56 μM. In MCF-7 cells, treatment with STK16-IN-1 results in a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine and paclitaxel results in a slight potentiation of the anti-proliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16)

体内研究：

STK16-IN-1 inhibits mTOR kinase (IC50: 5.56 μM). STK16-IN-1 shows potent inhibitory activity against STK16 kinase (IC50=0.295 μM) with excellent selective across the kinome as assessed using the KinomeScanTM profiling assay. STK16-IN-1 treatment causes a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16 in MCF-7 cells. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine and paclitaxel results in a slight potentiation of the anti-proliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16)

参考文献：

1. Liu F, et al. Discovery of a Highly Selective STK16 Kinase Inhibitor. ACS Chem Biol. 2016 Jun 17;11(6):1537-43.

溶解性：

Soluble in DMSO

保存条件：

2-8°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.409 ml	17.047 ml	34.095 ml
5 mM	0.682 ml	3.409 ml	6.819 ml
10 mM	0.341 ml	1.705 ml	3.409 ml
50 mM	0.068 ml	0.341 ml	0.682 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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