货号	规格	价格	上海	北京	珠海	重庆	武汉
S89249-5mg买3赠1	98.90%	￥450.00 S89249-5mg ￥450.00 现货（买3赠1）	5 5	-	-	-	-
S89249-10mg	98.90%	￥760.00 S89249-10mg ￥760.00 现货	6 6	-	-	-	-
S89249-25mg	98.90%	￥1520.00 S89249-25mg ￥1520.00 现货	5 5	-	-	-	-
S89249-100mg促销	≥98%	￥4530.00 ￥3620.00 S89249-100mg ￥3620.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat

靶点：

GDNF receptor RET;c-RET

体外研究：

BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET.

体内研究：

BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy. Animal Model: Rats induced by ligation of left L5 and L6 spinal nerves. Dosage: 5-25 mg/kg, dissolved in sesame oil containing 5% DMSO. Administration: Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12. Result: 20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.

参考文献：

1. Sidorova YA, et al. A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat. Front Pharmacol. 2017 Jun 21;8:365.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.932 ml	9.661 ml	19.322 ml
5 mM	0.386 ml	1.932 ml	3.864 ml
10 mM	0.193 ml	0.966 ml	1.932 ml
50 mM	0.039 ml	0.193 ml	0.386 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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