货号	规格	价格	上海	北京	珠海	重庆	武汉
S89293-5mg买3赠1	99.40%	￥450.00 S89293-5mg ￥450.00 现货（买3赠1）	4 4	-	-	-	-
S89293-10mg买3赠1	99.40%	￥580.00 S89293-10mg ￥580.00 现货（买3赠1）	6 6	-	-	-	-
S89293-25mg	99.40%	￥1000.00 S89293-25mg ￥1000.00 现货	2 2	-	-	-	-
S89293-100mg	≥98%	￥2800.00 S89293-100mg ￥2800.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553)是一种有效的 CD38 抑制剂，对人CD38和小鼠CD38的IC50分别为7.3 nM和1.9 nM

靶点：

mCD38(Cell-free assay):1.9 nM; hCD38(Cell-free assay):7.3 nM;CD38

体外研究：

CD38 inhibitor 1 (compound 78c) increases NAD+ levels, resulting in activation of pro-longevity and health span-related factors including sirtuins, AMPK, and PARPs

体内研究：

CD38 inhibitor 1 (compound 78c) is found to not only be a very potent inhibitor, but also had suitable physiochemical properties to serve as a robust tool for in vivo studies. In addition, CD38 inhibitor 1 (compound 78c) is able to elevate NAD in both liver and gastrocnemius tissue when dosed orally in a DIO mouse

细胞实验：

Cell lines: HEK293T, MEFs, A549, Jurkat T and AML12 cells Concentrations: 0.5 μM, 0.2 - 0.5 μM Incubation Time: 16 h, 24 h Method: To test the reversibility of the CD38i, A549 cells were treated with vehicle or 0.5 μM 78c for 16 hours. Then, cells were washed and incubated with (78c) or without (78c+release) 78c for another 8 hours.

动物实验：

Animal Models: DIO C57Bl6 mice Dosages: 30 mg/kg, 2 mg/kg Administration: Oral gavage, IV

参考文献：

1. Curt D Haffner, et al. Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem. 2015 Apr 23;58(8):3548-71. 2. Mariana G Tarragó, et al. A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline. Cell Metab. 2018 May 1;27(5):1081-1095.e10.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.418 ml	12.091 ml	24.182 ml
5 mM	0.484 ml	2.418 ml	4.836 ml
10 mM	0.242 ml	1.209 ml	2.418 ml
50 mM	0.048 ml	0.242 ml	0.484 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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