货号	规格	价格	上海	北京	珠海	重庆	武汉
S89342-5mg买3赠1	99.40%	￥610.00 S89342-5mg ￥610.00 现货（买3赠1）	5 5	-	-	-	-
S89342-10mg买3赠1	99.40%	￥860.00 S89342-10mg ￥860.00 现货（买3赠1）	6 6	-	-	-	-
S89342-25mg促销	99.40%	￥1210.00 ￥968.00 S89342-25mg ￥968.00 现货	5 5	-	-	-	-
S89342-100mg促销	≥98%	￥2500.00 ￥2000.00 S89342-100mg ￥2000.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A

靶点：

IC50: 0.8 μM (LMPTP-A);Phosphatase

体外研究：

LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50 of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes.

体内研究：

LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight.

参考文献：

1. Stanford SM1, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632.

溶解性：

Soluble in DMSO、H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.932 ml	9.661 ml	19.323 ml
5 mM	0.386 ml	1.932 ml	3.865 ml
10 mM	0.193 ml	0.966 ml	1.932 ml
50 mM	0.039 ml	0.193 ml	0.386 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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LMPTP INHIBITOR 1 dihydrochloride