| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89396-5mg买3赠1 |
99.60% | ￥850.00 |
6 | - | - | - | - |
|
S89396-10mg促销 |
99.60% | ￥1360.00 ￥1080.00 |
6 | - | - | - | - |
|
S89396-25mg促销 |
99.60% | ￥2550.00 ￥2040.00 |
5 | - | - | - | - |
|
S89396-100mg促销 |
≥98% | ￥5880.00 ￥4700.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9 | ||||||||||||||||||||
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| 靶点： | MAPK | ||||||||||||||||||||
| 体外研究： | ZINC05007751 (6 μM-190 μM; 24 hours) inhibits the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15 with IC50 below 100 µM. ZINC05007751 induces perturbation of PEO1 cell cycle. ZINC05007751 (ovarian cancer cells PEO1) shows synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1 µM, with combination ZINC05007751 (44 µM) + Cisplatin (10 µM) exhibiting the greatest synergistic effect. Cell Cytotoxicity Assay Cell Line: MDA-MB-231, PEO1, NCI-H1299 and HCT-15 cells Concentration: 6 μM-190 μM Incubation Time: 24 hours Result: Inhibited the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15. | ||||||||||||||||||||
| 参考文献： | 1. De Donato M, et al. Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6. Sci Rep. 2018;8(1):16047. Published 2018 Oct 30. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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