| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89487-5mg买3赠1 |
98.40% | ￥1700.00 |
3 | - | - | - | - |
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S89487-10mg买3赠1 |
98.40% | ￥2720.00 |
5 | - | - | - | - |
|
S89487-25mg买3赠1 |
98.40% | ￥4930.00 |
1 | - | - | - | - |
|
S89487-100mg |
98.40% | ￥10700.00 |
1 | - | - | - | - |
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| 产品描述： | AGX51 is a first-in-class pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. AGX51 inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids, cell growth arrest, and reduces viability. AGX51 inhibits the TNBC cell lines with IC50s of nearly 25 μM. AGX51 can be used for the research of cancer | ||||||||||||||||||||
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| 靶点： | IC50: 26.66 μM (4T1), 8.7 μM (HMLE RAS Twist), 22.28 μM (MDA-MB-157), 30.91 μM (MDA-MB-436), 36.55 μM (SK-BR-3), 60 μM (MCF-7), 10.89 μM (PDX-BR7), 11.97 μM (PDX-IBT) , 18.56 μM (PDX-BR11) | ||||||||||||||||||||
| 体外研究： | AGX51 (0 -80 μM；24 小时) 降低 4T1 细胞中的 ID1 蛋白水平。 AGX51 (40 μM；0-72 小时) 降低 40 μM 的 ID1 蛋白水平4T1细胞浓度。 AGX51 (40 μM；24 h) 影响4T1细胞、ER+、HER2+、TNBC和三种乳腺癌PDX细胞基因。 AGX51 (0 -80 μM；24-48 h) 影响 4T1 细胞周期。 AGX51 (40 μM；4-24 h)) 影响 4T1 细胞中的磷酸组蛋白 H3 水平。 AGX51 (40 μM；24 h) 影响 4T1 细胞中的 ROS 水平。 Western Blot Analysis Cell Line: 4T1 cells Concentration: 0, 5, 10, 20, 40 and 80 μM Incubation Time: 24 hours Result: Decreased ID1 protein levels starting at a concentration of 40 μM in 4T1 cells. Western Blot Analysis Cell Line: 4T1 cells Concentration: 40 μM Incubation Time: 0, 2, 4, 8 , 12, 24, 48 and 72 hours Result: Decreased ID1 protein levels starting at 4 h, while until 24 h ID1 protein completely loss. Cell Viability Assay Cell Line: 4T1 cells, HMLE RAS Twist, MDA-MB-157, MDA-MB-436, MDA-MB-231, MDA-MB-453, BT-474, MDA-MB-361, SK-BR-3, MCF-7, T47-D, PDX-BR7, PDX-IBT and PDX-BR11 Concentration: 40 μM Incubation Time: 24 hours Result: Inhibited 4T1, HMLE RAS Twist, MDA-MB-157, MDA-MB-436, SK-BR-3, MCF-7, PDX-BR7, PDX-IBT and PDX-BR11 cell lines with IC50s of 26.66, 8.7, 22.28, 30.91, 36.55, 60, 10.89, 11.97 and 18.56 μM, respectively. Cell Cycle Analysis Cell Line: 4T1 cells Concentration: 40 μM Incubation Time: 24 and 48 hours Result: Affected cell cycle of 4T1 cells with a G0/G1 phase accumulation. Cell Viability Assay Cell Line: 4T1 cells Concentration: 40 μM Incubation Time: 4 and 24 hours Result: Reduced phospho-histone H3 levels in 4T1 cells. Cell Viability Assay Cell Line: 4T1 cells | ||||||||||||||||||||
| 体内研究： | AGX51 (50 mg/kg；ip 每天两次，持续 4 周) 抑制肺转移。 AGX51 (15 mg/kg；ip 每天两次，持续 3 周) 表现出抗-具有自发性癌症的肿瘤活动。 Animal Model: Balb/c mice with luciferase-labeled 4T1 cells Dosage: 50 mg/kg Administration: Intraperitoneal injection; 60 mg/kg twice a day; for 4 weeks Result: Inhibited lung metastasis development. Animal Model: A/J mice with AOM colon tumor model Dosage: 15 mg/kg Administration: Intraperitoneal injection; 15 mg/kg twice a day; for 3 weeks Result: Dreased the colon tumors and exhibited anti-tumor activity in AOM colon tumor mice. | ||||||||||||||||||||
| 参考文献： | 1. Wojnarowicz PM, et al. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 Oct 1;29(1):62-75.e7. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO、Ethanol | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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营业执照(三证合一)
北京