货号	规格	价格	上海	北京	珠海	重庆	武汉
S89630-5mg	≥98%	￥650.00 S89630-5mg ￥650.00 2-3天	0 货期：2-3天	-	-	-	-
S89630-10mg买3赠1	99.80%	￥1100.00 S89630-10mg ￥1100.00 现货（买3赠1）	2 2	-	-	-	-
S89630-25mg买3赠1	99.80%	￥1600.00 S89630-25mg ￥1600.00 现货（买3赠1）	3 3	-	-	-	-
S89630-100mg	99.80%	￥5600.00 S89630-100mg ￥5600.00 现货	2 2	-	-	-	-

大包装询价收藏产品

加入购物车

产品描述：

ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC50s of 4.7 µM and 1.7 µM respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of autophagy

靶点：

TRPML1:4.7 μM (IC50);TRPML2:1.7 μM (IC50);TRPML3:12.5 μM (IC50);GlucagonReceptor

体外研究：

ML-SI3 (10 μM) inhibits ML-SA1-evoked Ca2+ signals in HeLa cells. ML-SI3 (25-75 μM, 24h) disrupts tegumental integrity of adult schistosomes. ML-SI3 (10 μM) blocks Rapamycin (HY-10219)-evoked ITRPML1 in mimic of lysosomal lumen. ML-SI3 (3 µM, 6 h) abolishes the increase in both LC3II and p62 levels induced by hypoxia/reoxygenation (H/R) (4 h H/2 h R) in neonatal rat ventricular myocytes (NRVM)

体内研究：

ML-SI3 (1.5 mg/kg, i.p., four times) attenuates I/R injury in mouse cardiomyocytes. Animal Model: Myocardial Ischemia/reperfusion (I/R) injury mice Dosage: 1.5 mg/kg Administration: Intraperitoneal injection (i.p.), four times before and during the in vivo I/R (ischemia 30 min and reperfusion 1 day) Result: Restored the blocked autophagic fux in the cardiomyocytes subjected to I/R.

参考文献：

1. Rühl P, et al. Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. Sci Rep. 2021 Apr 15;11(1):8313. 2. Kilpatrick BS, et al. Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx. J Cell Sci. 2016 Oct 15;129(20):3859-3867. 3. Bais S, et al. Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity. Biochimie. 2022 Mar;194:108-117. 4. Zhang X, et al. Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR. PLoS Biol. 2019 May 21;17(5):e3000252. 5. Xing Y, et al. Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy. Basic Res Cardiol. 2022 Apr 7;117(1):20.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.328 ml	11.639 ml	23.279 ml
5 mM	0.466 ml	2.328 ml	4.656 ml
10 mM	0.233 ml	1.164 ml	2.328 ml
50 mM	0.047 ml	0.233 ml	0.466 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

ML-SI3

N-(2-[4-(2-Methoxyphenyl)-1-piperazinyl]cyclohexyl)benzenesulfonamide

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)