货号	规格	价格	上海	北京	珠海	重庆	武汉
S89633-1mg买3赠1	98.30%	￥490.00 S89633-1mg ￥490.00 现货（买3赠1）	7 7	-	-	-	-
S89633-5mg买3赠1	98.30%	￥1590.00 S89633-5mg ￥1590.00 现货（买3赠1）	6 6	-	-	-	-
S89633-10mg	98.30%	￥2590.00 S89633-10mg ￥2590.00 现货	4 4	-	-	-	-

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产品描述：

Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II

靶点：

Topoisomerase; Caspase; Apoptosis; IAP; p53;Apoptosis; IAP; Caspase; Topoisomerase; p53

体外研究：

Phenoxodiol, at concentrations >or=1 microg/ml (4 microM), inhibited proliferation and reduced the viability of healthy donor-derived PBMC. In contrast, lower Phenoxodiol concentrations (0.05-0.5 microg/ml) augmented, upon 3-day incubation, peripheral blood mononuclear cells cytotoxicity. Experiments with purified CD56(+) lymphocytes revealed that Phenoxodiol enhanced the lytic function of natural killer cells by directly stimulating this lymphocytic subpopulation

体内研究：

Balb/C mice administered low-dose Phenoxodiol exhibited significantly reduced tumour growth rates and prolonged survival (in 40% of the animals) in a colon cancer model

参考文献：

1. Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110. 2. Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22(17):2611-20. 3. Georgaki S, et al. Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo. J Cell Mol Med. 2009 Sep;13(9B):3929-38.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	4.162 ml	20.811 ml	41.622 ml
5 mM	0.832 ml	4.162 ml	8.324 ml
10 mM	0.416 ml	2.081 ml	4.162 ml
50 mM	0.083 ml	0.416 ml	0.832 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

脱氢雌马酚

Phenoxodiol

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)