| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S89638-5mg买3赠1 |
99.80% | ￥630.00 |
6 | - | - | - | - |
|
S89638-10mg买3赠1 |
99.80% | ￥1020.00 |
7 | - | - | - | - |
|
S89638-25mg买3赠1 |
99.80% | ￥1950.00 |
3 | - | - | - | - |
|
S89638-100mg |
≥98% | ￥4460.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research | ||||||||||||||||||||
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| 靶点： | Wnt/β-catenin;Wnt/beta-catenin | ||||||||||||||||||||
| 体外研究： | HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway. HLY78 (20 μM, 0-48 h) significantly increases the colony formation ability by 2.78-fold and 2.88-fold for HGC-27 and AGS cells compared with the controls. HLY78 (20 μM, 0-48 h) elevates the migration ability of HGC-27 and AGS cells. HLY78 significantly increases TNKS expression, which is ameliorated by Dihydroartemisinin (HY-N0176). |
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| 体内研究： | HLY78 (0-1.8 mg/kg, Intranasal injection, once) attenuates neuronal apoptosis and improves neurological deficits through the LRP6/GSK3β/β-catenin signaling pathway after SAH (subarachnoid hemorrhage) in rats. Animal Model: Adult male Sprague-Dawley rats (280-310 g, n=9/group, SAH model) Dosage: 0, 0.2, 0.6, and 1.8 mg/kg Administration: Intranasal injection, once, at 1 h post-SAH (subarachnoid hemorrhage) Result: Significantly attenuated the short-term and long-term neurobehavioral deficits, as well as the neuronal apoptosis after SAH at 0.6 mg/kg. Successfully delivered into the brain via intranasal administration at 0.6 mg/kg and was sufficient to significantly increase the phosphorylation of LRP6. Reversed the changes of the Bcl-2, Bax, and cleaved caspase 3 levels. | ||||||||||||||||||||
| 参考文献： | 1. Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85. 2. Luo X, et al. HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats. Neurosci Bull. 2020 Oct;36(10):1171-1181. 3. Ma Y, et al. Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer. Oncol Lett. 2021 Oct;22(4):688. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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