货号	规格	价格	上海	北京	珠海	重庆	武汉
S89812-5mg买3赠1	99.50%	￥340.00 S89812-5mg ￥340.00 现货（买3赠1）	9 9	-	-	-	-
S89812-10mg买3赠1	99.50%	￥490.00 S89812-10mg ￥490.00 现货（买3赠1）	6 6	-	-	-	-
S89812-25mg促销	99.50%	￥730.00 ￥584.00 S89812-25mg ￥584.00 现货	6 6	-	-	-	-

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产品描述：

RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC50 of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects

靶点：

PDE Ⅳ:0.28 nM (IC50);PDE Ⅰ:>100 μM (IC50);PDE Ⅱ:160 μM (IC50);PDE Ⅲ:330 μM (IC50);PDE

体内研究：

RS-25344 hydrochloride (5 mg/kg; i.p.; twice daily for 72 h) results in significant increases in stomach weights in wild type C57BL/6 mice. RS-25344 hydrochloride (1 mg/kg; i.p.; 30 min prior to food bolus) increases gastric retention in mice

参考文献：

1. T Kaneko, et al. Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell Signal. 1995 Jul;7(5):527-34. 2. J D Fisch, et al. Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors. Hum Reprod. 1998 May;13(5):1248-54. 3. Will McDonough, et al. PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice. FASEB J. 2020 Sep;34(9):12533-12548.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.428 ml	12.142 ml	24.284 ml
5 mM	0.486 ml	2.428 ml	4.857 ml
10 mM	0.243 ml	1.214 ml	2.428 ml
50 mM	0.049 ml	0.243 ml	0.486 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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RS 25344 HCl