货号	规格	价格	上海	北京	珠海	重庆	武汉
S89825-5mg买3赠1	99.70%	￥224.00 S89825-5mg ￥224.00 现货（买3赠1）	5 5	-	-	-	-
S89825-10mg买3赠1	99.70%	￥340.00 S89825-10mg ￥340.00 现货（买3赠1）	9 9	-	-	-	-
S89825-25mg买3赠1	99.70%	￥636.00 S89825-25mg ￥636.00 现货（买3赠1）	2 2	-	-	-	-

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产品描述：

Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury

靶点：

Mitochondrial Metabolism;MitochondrialMetabolism

体内研究：

Mitochondrial fusion promoter M1 (2 mg/kg; i.v.) significantly protects rats with cardiac I/R injury against brain damage. Animal Model: Male Wistar rats (250-300g) receiving cardiac ischemia/reperfusion (I/R) Dosage: 2 mg/kg Administration: I.v. 15 minutes before cardiac I/R injury Result: Increased brain mitochondrial fusion.Increased blood-brain barrier (BBB) tight junction protein, and reduced macrophage inﬁltration in the brain.Reduced brain mitochondrial dysfunction and apoptosis, but it did not reduce mitochondrial oxidative stress.Reduced the expression of Alzheimer’s disease (AD)-related proteins.

参考文献：

1. Surinkaew P, et, al. Mitochondrial Fusion Promoter Alleviates Brain Damage in Rats with Cardiac Ischemia/Reperfusion Injury. J Alzheimers Dis. 2020;77(3):993-1003. 2. Wang D, et, al. A small molecule promotes mitochondrial fusion in mammalian cells. Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9302-5. 3. Asalla S, et, al. Restoring Mitochondrial Function: A Small Molecule-mediated Approach to Enhance Glucose Stimulated Insulin Secretion in Cholesterol Accumulated Pancreatic beta cells. Sci Rep. 2016 Jun 10;6:27513.

溶解性：

Soluble in DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.747 ml	13.734 ml	27.469 ml
5 mM	0.549 ml	2.747 ml	5.494 ml
10 mM	0.275 ml	1.373 ml	2.747 ml
50 mM	0.055 ml	0.275 ml	0.549 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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Mitochondrial Fusion Promoter M1