货号	规格	价格	上海	北京	珠海	重庆	武汉
T12825-10mg买3赠1	98.20%	￥160.00 T12825-10mg ￥160.00 现货（买3赠1）	1 1	-	-	-	-
T12825-25mg买3赠1	98.20%	￥320.00 T12825-25mg ￥320.00 现货（买3赠1）	6 6	-	-	-	-
T12825-50mg	98.20%	￥450.00 T12825-50mg ￥450.00 现货	5 5	-	-	-	-
T12825-100mg	98.20%	￥750.00 T12825-100mg ￥750.00 现货	4 4	-	-	-	-

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产品描述：

LAT1-IN-1 (BCH) 是 L 型氨基酸转运蛋白 1 (LAT1) 的选择性竞争性抑制剂，可显著抑制细胞对氨基酸的摄取和 mTOR 磷酸化，从而抑制癌细胞生长并诱导细胞凋亡。

靶点：

LAT1;Apoptosis; Others

体外研究：

LAT1-IN-1 (1-100 mM; 3 days; KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner.
LAT1-IN-1 (30 mM; 24 and 48 hours; KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase.
LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased.

体内研究：

LAT1-IN-1 (200 mg/kg; intravenous injection; daily; for 14 days; male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo.

参考文献：

1. Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107(10):1499-1505.

2. Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20(1).

3. Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5(4):1281-94. eCollection 2015.

溶解性：

soluble in H2O or DMSO

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	6.444 ml	32.219 ml	64.437 ml
5 mM	1.289 ml	6.444 ml	12.887 ml
10 mM	0.644 ml	3.222 ml	6.444 ml
50 mM	0.129 ml	0.644 ml	1.289 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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