货号	规格	价格	上海	北京	珠海	重庆	武汉
T20198-5mg买3赠1	99.80%	￥425.00 T20198-5mg ￥425.00 现货（买3赠1）	6 6	-	-	-	-
T20198-10mg买3赠1	99.80%	￥595.00 T20198-10mg ￥595.00 现货（买3赠1）	6 6	-	-	-	-
T20198-25mg买3赠1	99.80%	￥1190.00 T20198-25mg ￥1190.00 现货（买3赠1）	6 6	-	-	-	-
T20198-100mg买3赠1	99.80%	￥3570.00 T20198-100mg ￥3570.00 现货（买3赠1）	6 6	-	-	-	-

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产品描述：

DMU-212 is a methylated derivative of Resveratrol (HY-16561), with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2 protein. DMU-212 has orally active

靶点：

ERK;Apoptosis;Apoptosis; ERK

体外研究：

DMU-212 (0.3125-40 μM) 抑制 A375、MeWo、Bro 和 M5 人黑色素瘤细胞的生长。 DMU-212 (30-50 μM；24 小时) 诱导A375细胞中细胞周期抑制剂、细胞凋亡和ERK激活的上调。 Cell Proliferation Assay Cell Line: A375 cells, MeWo cells, M5 cells, Bro cells Concentration: 0.3125 μM, 0,625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time: 96 hours Result: Inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC50=0.5 μM for A375 and Bro and IC50= 1.25 μM for MeWo and M5 cells). Cell Cycle Analysis Cell Line: A375 cells Concentration: 20 μM, 30 μM, 50 μM Incubation Time: 24 hours Result: Caused a marked increase in the levels of p21, p53 and cyclin B1 proteins with a concomitant decrease in the levels of cyclin A2. Western Blot Analysis Cell Line: A375 cells Concentration: 20 μM, 30 μM, 50 μM Incubation Time: 24 hours Result: Significant upregulated Bax, caspase 3 and caspase 9 protein levels, while decreased the levels of the anti-apoptotic protein Bcl-2. Apoptosis Analysis Cell Line: A375 cells Concentration: 10 μM, 20 μM Incubation Time: 24 hours, 36 hours Result: Induced apoptosis.

体内研究：

DMU-212 (50 mg/kg；ig；每周 3 次；持续 14 天) 抑制人卵巢癌异种移植模型中的肿瘤生长。 Animal Model: 6-weeks-old SCID female mice (20-24 g), with ovarian cancer xenografts Dosage: 50 mg/kg Administration: Oral gavage, three times a week, for 14 days Result: Lowered tumor burden.

参考文献：

1. Vasilis Pericles Androutsopoulos, et al. Activation of ERK1/2 is required for the antimitotic activity of the resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) in human melanoma cells. Exp Dermatol. 2015 Aug;24(8):632-4. 2. Hanna Piotrowska, et al. DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer. Biomed Pharmacother. 2014 May;68(4):397-400.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.329 ml	16.647 ml	33.295 ml
5 mM	0.666 ml	3.329 ml	6.659 ml
10 mM	0.333 ml	1.665 ml	3.329 ml
50 mM	0.067 ml	0.333 ml	0.666 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

3,4,5,4'-四甲氧基二苯乙烯

3,4,5,4'-TETRAMETHOXYSTILBENE

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)