货号	规格	价格	上海	北京	珠海	重庆	武汉
T25405-5mg买3赠1	99.80%	￥195.00 T25405-5mg ￥195.00 现货（买3赠1）	5 5	-	-	-	-
T25405-10mg买3赠1	99.80%	￥310.00 T25405-10mg ￥310.00 现货（买3赠1）	6 6	-	-	-	-
T25405-25mg买3赠1	99.80%	￥490.00 T25405-25mg ￥490.00 现货（买3赠1）	5 5	-	-	-	-
T25405-100mg买3赠1	99.80%	￥880.00 T25405-100mg ￥880.00 现货（买3赠1）	2 2	-	-	-	-

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产品描述：

CDN1163 is an allosteric sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator that improves Ca2+ homeostasis. CDN1163 attenuates diabetes and metabolic disorders

靶点：

SERCA;CalciumChannel

体外研究：

CDN1163 (10?μM; 24 hours; rat cardiac myocyte cells) treatment reduces high glucose-induced resistin and nuclear NFATc expression and increases the phosphorylation of AMPKα in a time-dependent manner. Western Blot Analysis Cell Line: Rat cardiac myocyte cells (H9c2) Concentration: 10 μM Incubation Time: 24 hours Result: High glucose-induced resistin and nuclear NFATc expression are significantly reduced. The phosphorylation of AMPKα is increased in a time-dependent manner.

体内研究：

CDN1163 (50 mg/kg; intraperitoneal injection; for 5 days; male ob/ob mice and lean ob/+ mice) increases SERCA2 Ca2+-ATPase activity, decreases endoplasmic reticulum (ER) stress-induced cell death in vitro and improves liver Ca2+ transport activity. CDN1163 reduces blood glucose levels and improves metabolic parameters and gluconeogenic gene expression, reverses hepatic steatosis, inhibits ER stress and ER stress-induced apoptosis, and improves mitochondrial efficiency in ob/ob mice in vivo. Animal Model: Male 8-10-week old ob/ob mice and lean ob/+ mice Dosage: 50 mg/kg Administration: Intraperitoneal injection; for 5 days Result: Markedly lowered fasting blood glucose, improved glucose tolerance, and ameliorated hepatosteatosis but did not alter glucose levels or body weight. Increased expression of uncoupling protein 1 (UCP1) and UCP3 in brown adipose tissue and reduced the hepatic expression of genes involved in gluconeogenesis and lipogenesis, attenuated ER stress response and ER stress-induced apoptosis, and improved mitochondrial biogenesis, possibly through SERCA2-mediated activation of AMP-activated protein kinase pathway.

参考文献：

1. Kang S, et al. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J Biol Chem. 2016 Mar 4;291(10):5185-98. 2. Singh R, et al. A role for calcium in resistin transcriptional activation in diabetic hearts. Sci Rep. 2018 Oct 23;8(1):15633.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.121 ml	15.606 ml	31.212 ml
5 mM	0.624 ml	3.121 ml	6.242 ml
10 mM	0.312 ml	1.561 ml	3.121 ml
50 mM	0.062 ml	0.312 ml	0.624 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(1篇)

1. [IF=4.1] Xiaopeng Lu et al."Establishment and evaluation of targeted molecular screening model for the ryanodine receptor or sarco/endoplasmic reticulum calcium ATPase."PEST MANAGEMENT SCIENCE".2024 Feb;:

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

4-isopropoxy-N-(2-methylquinolin-8-yl)benzamide

CDN1163

参考文献(1篇)

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)