货号	规格	价格	上海	北京	珠海	重庆	武汉
T79046-10mg买3赠1	99.40%	￥120.00 T79046-10mg ￥120.00 现货（买3赠1）	405 >10	-	-	-	-
T79046-50mg买3赠1	99.40%	￥172.00 T79046-50mg ￥172.00 现货（买3赠1）	87 >10	-	-	-	-
T79046-100mg买3赠1	99.40%	￥248.00 T79046-100mg ￥248.00 现货（买3赠1）	46 >10	-	-	-	-

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产品描述：

VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 µg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95%

靶点：

Bacterial;Antibiotic

体外研究：

VP-4604 (2.5 mM, 18 hours) inhibits drug-resistant S. aureus and P. aeruginosa with growth inhibiton (%) GI >95%. VP-4604 shows low cytotoxicity with a CC50 value >118.4 mM towards HEK-293 (human embryonic kidney) ATCC CRL‐1573 and an HC10 vaule >118.4 μM towards RBC (human red blood cells). VP-4604 (2.5 mM) is tolerated by mammalian cells (HaCaT, lymphocytes) with the inhibition growth (%) of 44.1% and >50%, respectively. Cell Proliferation Assay Cell Line: S. aureus ATCC25923, P. aeruginosa ATCC9027 Concentration: 0.625 mM, 1.25 mM, 2.5 mM Incubation Time: 18 hours Result: Showed antibacterial effect. Cell Cytotoxicity Assay Cell Line: HaCaT line (human keratinocytes), lymphocytes (from healthy adult human peripheral blood) Concentration: 0, 1, 10, 100, 1000, 2500 μM Incubation Time: 48 or 72 hours Result: Showed low toxicity towards mammalian cells.

参考文献：

1. Vitalii Palchykov, et al. Antimicrobial action of arylsulfonamides bearing (aza)norbornane and related motifs: evaluation of new promising anti-MRSA agents. Medicinal Chemistry Research. 2022. 31: 284-292.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.7 ml	18.498 ml	36.996 ml
5 mM	0.74 ml	3.7 ml	7.399 ml
10 mM	0.37 ml	1.85 ml	3.7 ml
50 mM	0.074 ml	0.37 ml	0.74 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

VP-4604

1-[(4-NITROPHENYL)SULFONYL]PIPERIDINE

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)