75. [IF=2.6] Xuemei Xu, et al. "A Strategy of Screening Drug Combination From Traditional Chinese Medicine Based on Biomimetic Extracted Substances: Bufei Yishen Formula as a Case"PHYTOCHEMICAL ANALYSIS, 2026 Apr;: 74. [IF=7.8] Fu Yao, et al. "Integrated multi-omics maps how processed black ginseng modulates gut homeostasis through rare ginsenosides"npj Science of Food, 2026 Apr;: 73. [IF=11.3] Lei Jia, et al. "Ginsenoside Ro ameliorates D-galactose-induced sarcopenia by modulating oxidative stress, inflammation, and gut microbiota in mice"PHYTOMEDICINE, 2026 May;:158307 72. [IF=4.6] Qi Wang et al."Catalytic Transformation of Ginsenoside Re over Mesoporous Silica-Supported Heteropoly Acids: Generation of Diverse Rare Ginsenosides in Aqueous Ethanol Revealed by HPLC-HRMSn."MOLECULES.2025 Dec;30(24):4753 71. [IF=3.5] Tingting Dai et al."Ginsenoside Rh1 inhibits tumor growth in mice with colorectal cancer and depressive symptoms via modulation of the gut microbiota and tumor microenvironment."Molecular Medicine Reports.2025 Dec;32(6):1-17 70. [IF=8.3] Wen Li et al."Ginsenoside compound K ameliorates depressive-like behaviors by targeting kynurenine 3-monooxygenase."PHYTOMEDICINE.2025 Sep;:157335 69. [IF=3.2] Zhang Xiaohong et al."Ginsenoside Rh7 affects β-catenin nuclear translocation by inhibiting SHCBP1 expression, thereby inhibiting epithelial-mesenchymal transition in gastric cancer cells."International Journal of Medical Sciences.2025 Jun;22(12):3053-306 68. [IF=3.8] Jiangang Wang et al."Ginsenoside Rh1 Alleviates Allergic Rhinitis by Mediating Mitochondrial Autophagy via Activation of the AMPK/ULK1/FUNDC1 Pathway."Food Science & Nutrition.2025 Jun;13(6):e70464 67. [IF=8.5] Chengcheng Li et al."Cellulase hyperproduction Trichoderma reesei mutant strain BB8 for the bioextraction and bioconversion of ginsenoside from Panax notoginseng."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 Jun;:144984 66. [IF=3.8] Qin Wei et al."Target Identification of Ginsenosides Against Cognitive Impairment by Using Mass Spectrometry-Based Cellular Thermal Shift Assay (CETSA)."NEUROCHEMICAL RESEARCH.2025 Jun;50(3):1-17 65. [IF=4.6] Yanyan Chang et al."Diverse rare ginsenosides derived from ginsenoside Re in aqueous methanol solution via heterogeneous catalysis and identified by HPLC-MS."RSC Advances.2025 May;15(21):16455-16467 64. [IF=4.4] Ye Qiu et al."Changes in the chemical composition and medicinal effects of black ginseng during processing."Frontiers in Pharmacology.2024 Nov;15: 63. [IF=4.9] Yaru Zhao et al."Weighted Gene Co-Expression Network Based on Transcriptomics: Unravelling the Differentiation Dynamics of 3T3-L1 Preadipocytes and the Regulatory Mechanism of Protopanaxatriol."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2024 Nov;25(22):1 62. [IF=2.9] Wei Zhang et al."Effects of water stress on secondary metabolism of Panax ginseng fresh roots."PLoS One.2024 Nov;19(11):e0312023 61. [IF=3.1] Ze-xuan Chen et al."Metabolite profiling of Shenhua compound in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL 60. [IF=4] Di Yang et al."Multidimensional comparison of different specifications and grades of Sanqi (the root and rhizome of Panax notoginseng): Low saponin content is linked to high starch content."JOURNAL OF FOOD COMPOSITION AND ANALYSIS.2025 Mar;139:107139 59. [IF=3.8] Zhang Wei et al."Mechanism of sodium nitroprusside regulating ginseng quality."Scientific Reports.2025 Jan;15(1):1-19 58. [IF=3.2] Chang Wang et al."Different processing methods affect the chemical composition and in vitro anti-tumor activity of ginseng."JOURNAL OF FOOD SCIENCE.2025 Jan;90(1):e17639 57. [IF=6.2] Peng Yu et al."Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice."Current Research in Food Science.2025 Jan;10:100978 56. [IF=6.7] Xinguang Liu et al."Screening effective-component compatibility from Jinshui Chenfei formula for silicosis treatment by serum-pharmacochemistry and feedback system control."PHYTOMEDICINE.2025 Mar;138:156419 55. [IF=4.9] Yao Fu et al."Delayed luminescence: An effective measurement for determining the growth ages of forest cultivated ginseng."MICROCHEMICAL JOURNAL.2025 Jan;:112921 54. [IF=6.7] Meng Zhang et al."Exploring the Anti-Fatigue Properties of Ginseng Stem and Leaf Saponins: Using UHPLC-MS Metabolomics and Neurotransmitter Analysis."PHYTOMEDICINE.2025 Feb;:156459 53. [IF=6] Qianju Sun et al."Investigation of the dynamic alteration in delayed luminescence property and their correlation with ginsenoside over the classical nine-cycle steaming and drying processing of black ginseng."LWT-FOOD SCIENCE AND TECHNOLOGY.2025 Feb;218:1 52. [IF=3.8] Saiya Chen et al."Molecular network strategies combined with MCnebula2 identify potential active compounds from steamed Polygonatum cyrtonema Hua."JOURNAL OF CHROMATOGRAPHY A.2025 Feb;:465779 51. [IF=2.8] Ruobing Bai et al."Total ginsenosides from wild ginseng improve immune regulation in a rat model of spleen qi deficiency by modulating fecal-bacteria-associated short-chain fatty acids and intestinal barrier integrity."JOURNAL OF CHROMATOGRAPHY B-ANALYTIC 50. [IF=6.8] Feiyan Chen et al."Identification of AIF1 as a protein target of notoginsenosides in brain tissue of mice with intracerebral hemorrhage based on hapten immunoaffinity fishing technique."Journal of Ginseng Research.2025 Apr;: 49. [IF=2.9] Ning Xu et al."Water extract of ginseng alleviates parkinsonism in MPTP–induced Parkinson’s disease mice."PLoS One.2024 Sep;19(9):e0296424 48. [IF=4.3] Wu Dehua et al."Temperature seasonality and soil phosphorus availability shape ginseng quality via regulating ginsenoside contents."BMC PLANT BIOLOGY.2024 Dec;24(1):1-12 47. [IF=3.3] Rong Liu et al."Characterization of a Xylosyltransferase from Panax notoginseng Catalyzing Ginsenoside 2′-O Glycosylation in the Biosynthesis of Notoginsenosides."JOURNAL OF NATURAL PRODUCTS.2024;XXXX(XXX):XXX-XXX 46. [IF=5.4] Yingqiu Shi et al."Effective constituents and protective effect of Mudan granules against Schwann cell injury."JOURNAL OF ETHNOPHARMACOLOGY.2024 Apr;323:117692 45. [IF=9.3] Weiwei Zheng et al."Ginsenoside Rh1, a novel casein kinase II subunit alpha (CK2α) inhibitor, retards metastasis via disrupting HHEX/CCL20 signaling cascade involved in tumor cell extravasation across endothelial barrier."PHARMACOLOGICAL RESEARCH.2023 Dec; 44. [IF=6.1] Yue-guang Mi et al."Comparative Characterization of the Ginsenosides from Six Panax Herbal Extracts and Their In Vitro Rat Gut Microbial Metabolites by Advanced Liquid Chromatography–Mass Spectrometry Approaches."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 43. [IF=3.2] Yuqing Xu et al."Optimization of Rare Ginsenosides and Antioxidant Activity Quality of Ginseng Jiaosu Based on Probiotic Strains and Fermentation Technology."JOURNAL OF FOOD QUALITY.2023;2023:5686929 42. [IF=5.735] Feiyan Chen et al."Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction."Journal of Ginseng Research.2023 Apr;: 41. [IF=1.193] Song Fengyuan et al."Preparation of solid dispersion of Dushen decoction and establishment of its evaluation method."CHINESE JOURNAL OF ANALYTICAL CHEMISTRY.2023 Mar;:100259 40. [IF=7.675] Siming Wang et al."Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19- and SDH2-Mediated Cellular Metabolism."Antioxidants.2023 Feb;12(2):296 39. [IF=4.478] Ren, Rongfan et al."Characterization of ginsenoside structural isomers from mixtures using in situ methylation with direct analysis in real-time ionization tandem mass spectrometry."ANALYTICAL AND BIOANALYTICAL CHEMISTRY.2022 Dec;:1-11 38. [IF=2.893] Zhong Peng et al."Characterization of a novel thermophilic beta-glucosidase from Thermotoga sp. and its application in the transformation of notoginsenoside R1."3 Biotech.2022 Nov;12(11):1-14 37. [IF=3.571] Jie Mei et al."Quality evaluation of Panax notoginseng (Burk.) F.H. Chen using supercritical fluid chromatography–mass spectrometry and chemical pattern recognition."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2022 Nov;221:115029 36. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199 35. [IF=6.055] Baoyu Fu et al."Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway."Frontiers in Endocrinology.2022; 13: 964069 34. [IF=2.586] Wei Li et al."Ultra high-performance liquid chromatography coupled to ion mobility quadrupole time of flight mass spectrometry profiling and unveiling the transformation of ginsenosides by the dual conditions of citric acid and high-pressure steaming."RAP 33. [IF=5.988] 32. [IF=3.318] Hongda Sheng et al."Identification of bioactive ingredients from Babaodan using UPLC-QTOF-MS analysis combined with network pharmacology guided bioassays."JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES.2022 Aug;120 31. [IF=1.885] Guo Na et al."Comparison of the Saponins in Three Processed American Ginseng Products by Ultra-High Performance Liquid Chromatography-Quadrupole Orbitrap Tandem Mass Spectrometry and Multivariate Statistical Analysis."International Journal of Analytical Ch 30. [IF=6.06] Zhu Zhu et al."Target engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability."J Ginseng Res. 2021 Dec;: 29. [IF=6.06] Qingxia Huang et al."Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons."J Ginseng Res. 2022 Feb;: 28. [IF=3.167] Jingqi Zhao et al."Complexation mechanism between 20(R, S)-ginsenoside Rh1 and serum albumin: Multi-spectroscopy, in vitro cytotoxicity, and in silico investigations."Journal Of Food Science. 2022 Feb 01 27. [IF=2.419] Yinping Jin et al."Dynamic changes of ginsenosides in Panax quinquefolius fruit at different development stages measured by UHPLC-Orbitrap MS."Rapid Communications In Mass Spectrometry. 2022 Feb 17 26. [IF=2.408] Fang-Tong Li et al."In Vitro Effects of Ginseng and the Seed of Zizyphus jujuba var. spinosa on Gut Microbiota of Rats with Spleen Deficiency."Chem Biodivers. 2020 Sep;17(9):e2000199 25. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556 24. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 23. [IF=3.647] Wenqi Jin et al."Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells."Life Sci. 2020 Mar;245:117337 22. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 21. [IF=4.36] Yongshen Ren et al."Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational analysis combined with UPLC-MS and molecular docking."J Ethnopharmacol. 2020 Oct;260:112955 20. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136 19. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89 18. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 17. [IF=3.935] Hong Zhang et al."A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry for the analysis of ginsenosides from white a 16. [IF=3.935] Hong-Mei Zhang et al."Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach."J Pharmaceut Biomed. 2012 Mar;62:258 15. [IF=4.36] Bin Ma et al."Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng."J Ethnopharmacol. 2017 Jan;195:222 14. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 13. [IF=6.06] Yang Xiu et al."Simultaneous determination and difference evaluation of 14 ginsenosides in Panax ginseng roots cultivated in different areas and ages by high-performance liquid chromatography coupled with triple quadrupole mass spectrometer in the multipl 12. Yongshen Ren, Jiao Ai, Xinqiao Liu, Shuai Liang, Yao Zheng, Xin Deng, Yan Li, Jing Wang, Xukun Deng, Lin-Lin Chen, Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational anal 11. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu, A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 10. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu, A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 9. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu, A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 8. Qin, Z., Jia, M., Yang, J. et al. Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug–drug interactions. Chin Med 15, 69 (2020). https://doi.o 7. Zhang, Hong-Mei, et al. "Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach." Journal of pharmaceutical and biomedical analysis 62 (2012): 258-273.https://doi.org/10.1016/j.jpba.2012.01.010 6. 越皓,周东月,张美玉,张琰,戴雨霖,郑飞,朱英豪.红参中原人参三醇型皂苷组在肠道菌群中体外转化及对肠道菌群的作用[J].应用化学,2021,38(03):323-330. 5. 夏晚霞, 张尚微, 葛亚中,等. 乳酸菌发酵转化人参皂苷[J]. 现代食品科技, 2018, 34(09):136-142. 4. 张琰, 李方彤, 韩铭鑫,等. 通过RRLC-Q-TOF MS和UPLC-QQQ MS分析原人参三醇型皂苷在人肠道菌群中的代谢产物[J]. 质谱学报, 2020(1):66-75. 3. 张博, 孙秀丽, 郭云龙,等. 液质联用技术分析不同产地不同年限人参的化学成分[J]. 中国实验方剂学杂志, 2020年26卷8期, 206-212页, ISTIC PKU CSCD CA, 2020. 2. 董坤园, 于澎, 熊金路,等. 基于高效液相色谱图谱结合化学计量学的红参指纹图谱研究[J]. 食品安全质量检测学报, 2019, 010(021):7316-7321. 1. 钟雅婷 茅仁刚 宋纯清 等. RP-HPLC同时测定西洋参总皂苷转化产物中人参皂苷Rg1 Rh1 Rd Rg3和C-K的含量[J]. 江西中医药 2012 43(8):61-64.